GPC1

(redirected from glypican-1)

GPC1

A gene on chromosome 2q35-q37 that encodes glypican 1, a cell surface proteoglycan with heparan sulfate that contains a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) bond. The GPC family plays a role in controlling cell division and growth regulation.

Molecular pathology
Defects in processing glypican 1 occur in fibroblasts of patients with Niemann-Pick Type C1 disease.
References in periodicals archive ?
The simple MiCheck technology uses Glypican-1, a newly identified biomarker.
A number of components of the prostaglandin synthesis system-cyclooxygenase-2 (COX-2), secretory phospholipase A2 group: IIA, V, and IB (sPLA2-IIA, sPLA2-V, sPLA2-IB), glypican-1, PG-E synthase, PG-E receptors, and lysophosphatidic acid receptor 3 (LPA3) have been estimated and very low levels of sPLA2-IIA and COX-2 were measured in 85% of RIF patients.
Expression of the heparan sulfate proteoglycan glypican-1 in the developing rodent.