GPC3

(redirected from glypican 3)

GPC3

A gene on chromosome Xq26.1 that encodes glypican 3, a cell surface proteoglycan with heparan sulfate that inhibits the dipeptidyl peptidase activity of DPP4. It may be involved in modulating growth of mesodermal tissues, in IGF2-receptor interactions, and in cellular growth and tumourigenesis.

Molecular Pathology
Defects in GPC3 cause Simpson-Golabi-Behmel syndrome.
References in periodicals archive ?
In March 2015, CARsgen and Renji Hospital initiated a Phase 1 clinical study to evaluate the safety and early-stage efficacy of CARsgen's glypican 3 (GPC3) chimeric antigen receptor T-cell (CAR-T) therapy.
An immunohistochemical stain for [alpha]-fetoprotein was equivocal and stains for both hepatocyte antigen and glypican 3 were negative.
Stains for [alpha]-fetoprotein, hepatocyte antigen, and glypican 3 (Figure 5) were positive in the residual fetal and embryonal epithelial hepatocytic areas in the left lobe nodule, but were completely negative in the basaloid squamous and glandular areas.
Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis.
The agreement covers exclusive, worldwide rights to a diagnostic test system to detect primary liver cancer (HCC), using a unique monoclonal antibody to glypican 3 (GPC3), known to have increased expression in HCC, and shown to be detectable in tissue specimens and serum.