glycosylphosphatidylinositol


Also found in: Dictionary, Encyclopedia, Wikipedia.

glycosylphosphatidylinositol

(glī″kō-sĭl-fŏs′fă-tī-dĭl-ĭn-ŏs′ĭ-tŏl″),

GPI

A lipid in the plasma membrane of cells that anchors proteins on the cell's surface. Some of the proteins held on the cell surface protect cells against attack by serum complement. Mutations that decrease or eliminate GPI are responsible for the destruction of blood cells by the complement system, which characterizes the disease called paroxysmal nocturnal hemoglobinuria.
References in periodicals archive ?
Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma.
The glycosylphosphatidylinositol (GPI) anchor of malarial membrane proteins may cause cellular dysfunction, but a role for this toxin in dyserythropoiesis remains to be established (26).
In contrast to most existing vaccines, the new vaccine targets not proteins on the pathogen's exterior but rather a compound called glycosylphosphatidylinositol (GPI) that seems to cause malaria's most deadly symptoms--and may be a long-sought malaria toxin.
These chambers were rich in proteins that use a specific chemical anchor (called glycosylphosphatidylinositol or GPI) to stick to the cell membrane, the Dallas researchers note.
Special emphasis is placed on glycosylphosphatidylinositol (GPI) anchoring, ABC phospholipid translocators, elongation factor-2 and calcineurin.
Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.
The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor.
HJV contains a C-terminal putative transmembrane domain characteristic of a glycosylphosphatidylinositol (GPI)-linked membrane anchor.

Full browser ?