glycosylation


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glycosylation

 [gli-ko″-sĭ-la´shun]
the formation of linkages with glycosyl groups.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn),
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the elevated concentration of d-glucose in blood concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin.

glycosylation

/gly·co·syl·a·tion/ (gli-ko″sĭ-la´shun) the formation of linkages with glycosyl groups.

glycosylation

(glī′kō-sĭ-lā′shən)
n.
The addition of saccharides to proteins or lipids to form a glycoprotein or glycolipid.

gly·co′sy·late′ v.

glycosylation

[glīkə′səlā′shən]
the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn)
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the raised blood d-glucose concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin

glycosylation

the addition of a CARBOHYDRATE to an organic molecule such as a PROTEIN.

glycosylation (glī·kōˈ·s·lāˑ·shn),

n process in which a carbohydrate is covalently attached to another molecule.

glycosylation

the formation of linkages with glycosyl groups.

N-linked glycosylation
attachment of oligosaccharides, synthesized on a dolichol-lipid platform to proteins through the amino acid asparagine spaced close to threonine or serine in the polypeptide sequence.
O-linked glycosylation
attachment of groups of oligosaccharides directly to proteins through the hydroxyl group of threonine.
References in periodicals archive ?
Glycosylation site alteration in the evolution of influenza A (H1N1) viruses.
When the researchers analyzed human breast and lung tumor tissues, they found GlcNAc-related glycosylation was elevated two- to fourfold in the majority of tumors relative to normal tissue from the same patients.
Glycosylation defects alter insulin but not insulin-like growth factor 1 binding to Chinese hamster ovary (CHO) cells.
A defect in this transportation results in a less efficient process of glycosylation.
The main results are: (a) glycosylation degree and pattern of ML are influencing the recognition of galactosyl/acetylgalactosyl groups of the lectin targets, (b) fucose and mannose binding plant lectins--serving as models for membrane bound cellular lectins--show a different binding pattern to the truncated ML glycoforms, and (c) the recognition of ML glycoforms by a panel of monoclonal antibodies is not influenced markedly contrary to the results giving polyclonal antibodies.
Heterogeneity due to cell specific glycosylation and tissue culture conditions are discussed with main emphasis on N-glycosylation sequon occupancy.
The complexity and diversity of glycosylation significantly complicates the linkage between genetic sequence and mature, active proteins.
The Dow Chemical Company has acquired a global, exclusive assignment of patents involving significant technology in protein glycosylation for enabling the production of 'mammalian-like' glycans in plants.
Maintain blood sugar levels to avoid excessive glycosylation and increased stiffness of tissue.
This scientific program will focus on the use of MaxCyte's proprietary large scale transfection platform in combination with Cevec's CAP-T technology for the production of proteins and antibodies with authentic human glycosylation and sialylation.
The fundamental understanding of these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and several cancers to be defined, which will facilitate the identification of effective treatments and diagnostics for these conditions in due course.
Changes in glycosylation are often a hallmark of disease states such as cancers, virus infection, etc.

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