glycosylation


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glycosylation

 [gli-ko″-sĭ-la´shun]
the formation of linkages with glycosyl groups.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn),
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the elevated concentration of d-glucose in blood concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin.

glycosylation

/gly·co·syl·a·tion/ (gli-ko″sĭ-la´shun) the formation of linkages with glycosyl groups.

glycosylation

(glī′kō-sĭ-lā′shən)
n.
The addition of saccharides to proteins or lipids to form a glycoprotein or glycolipid.

gly·co′sy·late′ v.

glycosylation

[glīkə′səlā′shən]
the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn)
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the raised blood d-glucose concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin

glycosylation

the addition of a CARBOHYDRATE to an organic molecule such as a PROTEIN.

glycosylation (glī·kōˈ·s·lāˑ·shn),

n process in which a carbohydrate is covalently attached to another molecule.

glycosylation

the formation of linkages with glycosyl groups.

N-linked glycosylation
attachment of oligosaccharides, synthesized on a dolichol-lipid platform to proteins through the amino acid asparagine spaced close to threonine or serine in the polypeptide sequence.
O-linked glycosylation
attachment of groups of oligosaccharides directly to proteins through the hydroxyl group of threonine.
References in periodicals archive ?
The TML group has been studying glycosylation mechanisms to elucidate which mutations in patients affect the mechanisms of glycosylation.
To further verify the altered glycopatterns between DN and NDRD patients, lectin blotting was used to characterize the differences of glycosylation in protein level.
As Lectins can be used to detect and analyze glycoprotein function, Creative BioMart also provides services utilizing lectins, which include Glycoprotein identification, Glycoprotein purification/enrichment, Characterization of cell surface glycoconjugates, Glycosylation mutant generation, as well as Gtf and glycosidase activity analysis.
Interestingly, in spite of the large bond-dissociation energy of the C-F bond, the desired glycosylation reaction proceeded smoothly with Sn[Cl.
During the development process, AIST took charge of developing clinically useful glycosylation marker candidates for diagnosing hepatic fibrosis, while Sysmex developed an automated measurement system (HISCL-Series automated immunoassay system and HISCL M2BPGi Assay Kit, a hepatic fibrosis test reagent) to be used as an alternative to lectin arrays.
Glycosylation site alteration in the evolution of influenza A (H1N1) viruses.
EX-CELL Glycosylation Adjust (Gal+) is an off-the-shelf protein quality supplement designed to achieve functionally relevant shifts in N-linked glycosylation quickly and efficiently, according to the company, and is highly concentrated, only requiring a small amount of product.
Its early elution in the original SEC, compared with the globular standards, may be explained by changes in its hydrodynamic properties due to glycosylation.
The research team -- led by Linda Hsieh-Wilson, professor of chemistry at Caltech -- found that tumor cells alter glycosylation, the addition of carbohydrates (in this case GlcNAc) to their proteins, in response to their surroundings.
Glythera, England, an emerging biopharmaceutical company specialising in protein/peptide functionalisation and glycosylation, has secured a fundraising round totalling GBP2M with IP Group, which will be tranched over the next three years.

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