glycosphingolipid


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glycosphingolipid

 [gli″ko-sfing″o-lip´id]
a fatty acid containing the carbohydrate sugar glucose or galactose.

gly·co·sphin·go·lip·id

(glī'kō-sfing'gō-lip'id),
A ceramide linked to one or more sugars through the terminal OH group; included as glycosphingolipids are cerebrosides, gangliosides, and ceramide oligosaccharides (oligoglycosylceramides). The prefix glyc- may be replaced by gluc-, galact-, lact-, etc.
Synonym(s): ceramide saccharide

glycosphingolipid

/gly·co·sphingo·lip·id/ (gli″ko-sfing″go-lip´id) any sphingolipid in which the head group is a mono- or oligosaccharide; included are the cerebrosides, sulfatides, and gangliosides.

gly·co·sphin·go·lip·id

(glī'kō-sfing'gō-lip-id)
A ceramide linked to one or more sugars through the terminal OH group; included as glycosphingolipids are cerebrosides, gangliosides, and ceramide oligosaccharides (oligoglycosylceramides). The prefix glyc- may be replaced by gluc-, galact-, and lact-.

glycosphingolipid

a sphingolipid containing the sugar glucose or galactose.
References in periodicals archive ?
Extensive research has identified the glycosphingolipid globotriaosyl ceramide (Gb3 or CD77) as the receptor for Shiga toxin (verotoxin) and the bacterial pilin papG protein.
Hepatocyte plasma membrane glycosphingolipid reactive with sera from patients with autoimmune chronic active hepatitis; its identification as sulfatide.
The second business unit is focused on the development of therapeutics to treat inherited glycosphingolipid (GSL) storage disorders.
Antibodies to glycosphingolipid antigens in patients with immune-mediated cochleovestibular disorders.
A case of GM1-gangliosidosis type I: glycosphingolipid profiles of urine and transformed lymphocytes and beta-D-galactosidase activities in peripheral lymphocytes, cultured skin fibroblasts and transformed lymphocytes.
The glycosphingolipid Gb3 (CD77) found in germinal center stage B cells and Burkitt's lymphoma cells has roles in apoptosis, cell adhesion, and interferon type I signaling.
Fabry's disease is an X-linked disorder of glycosphingolipid catabolism related to the defective activity of glycosphingolipid, mainly ceramide trihexoside, in the vascular smooth muscle, myocardium, cells of the sympathetic central nervous system, and epithelial cells of renal glomeruli.
Oxford has drug research and discovery programmes in central nervous system, cancer, infectious disease and glycosphingolipid storage disorders.
Differential regulation of glycosphingolipid biosynthesis in phenotypically distinct Burkitt's lymphoma cell lines.
Metabolic cytometry - the study of glycosphingolipid metabolism in single primary cells of the dorsal root ganglia
In substrate reduction therapy (SRT), the synthesis of glycosphingolipids is reduced by partial inhibition of glucosylceramide (G1cCer) synthase by deoxynojirimycin analogs (5), leading to reduction of the glycosphingolipid pool and eventually to reduction of the substrate load for lysosomal degradation by sphingolipid hydrolases.