GP6

(redirected from glycoprotein VI)

GP6

A gene on chromosome 19q13.4 that encodes a 58-kD platelet membrane glycoprotein, which plays a central role in the collagen-induced platelet activation and aggregation. Injury to the vessel wall and damage to the endothelial lining exposes the subendothelial matrix to blood flow, resulting in deposition of platelets. Collagen, especially types I, III and VI, are the most thrombogenic macromolecules of the extracellular matrix. The adhesion of platelets to collagen results in activation, leading to platelet secretion, recruitment of additional platelets and aggregation resulting in a platelet plug, which limits blood loss. However, collagen exposure after rupture of atherosclerotic plaques results in thrombus formation and may lead to myocardial infarction or stroke.
References in periodicals archive ?
Its other product candidates under development also comprise REG2, which is in Phase 1 clinical trial for the treatment of venous thrombosis indication; and REG3, a preclinical stage antiplatelet therapy consisting of glycoprotein VI inhibitor for diabetic vasculopathy and other inflammatory diseases.
Aegyptin will recognize and bind to specific platelet glycoprotein VI (GP VI), integrin [alpha]2[beta]1 and VWF (von Willebrand factor) so that the interaction between platelets and collagen will be prevented.
Aegyptin, a novel mosquito salivary gland protein specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin [alpha]2[beta]i and von Willebrand factor.
6] Platelet collagen receptor glycoprotein VI (pGPVI) is the key regulator of platelet activation and aggregation at sites of vascular injury where collagen is exposed (1, 2).
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo.
Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot study.
This was accompanied by reduced tyrosine phosphorylation of the tyrosine kinase Syk and phospholipase Cgamma2, components of the platelet glycoprotein VI collagen receptor signaling pathway.
Glycoprotein VI is a major platelet glycoprotein (60-65 kd) that has been considered a putative receptor for collagen since the identification of a patient with a mild bleeding disorder whose platelets lacked GPVI and exhibited defective collagen-induced responses.
Glycoprotein VI complementary DNA (35,36,62,63) has an open reading frame of 1017 base pairs coding for a protein of 339 amino acids, including a putative 20-amino-acid signal sequence (62) and a 19-amino-acid transmembrane domain between residues 270 and 288.
The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to Fc[alpha][psi] and the natural killer receptors.
The GP6 gene encodes glycoprotein VI, a 58-kDa platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets and may play a role in DVT.
Effect of factor Xa, thrombin and new anticoagulants on human platelet glycoprotein VI (GPVI) expression and GPVI-mediated coagulation