glycogen synthase

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gly·co·gen syn·thase

, glycogen starch synthase
a glucosyltransferase catalyzing the incorporation of d-glucose from UDP-d-glucose into 1,4-α-d-glucosyl chains. A deficiency of the liver enzyme may lead to a type of hypoglycemia.


a polysaccharide, the chief carbohydrate storage material in animals. It is formed and stored in the liver and muscles (phosphorylytically cleaved to glucose-1-phosphate). Called also animal starch.

glycogen granules
electron-dense accumulation of glycogen molecules.
glycogen nephrosis
deposition of glycogen in the renal tubules in diabetes mellitus but without apparent effect on renal function.
glycogen phosphorylase
glycogen phosphorylase the major enzyme in glycogenolysis, leading to the release of glucose-1-phosphate from glycogen. This enzyme is activated by phosphorylation from ATP by glycogen phosphorylase kinase, activated by cAMP-dependent protein kinase or by Ca2+ via calmodulin, or inhibited by hydrolysis of the phosphate by glycogen phosphorylase phosphatase.
glycogen synthase
an enzyme in the glycogenesis process.
References in periodicals archive ?
An acute increase in fructose concentration increases hepatic glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats.
Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of [beta]-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes.
Exercise training and dietary chromium effects on glycogen, glycogen synthase, phosphorylase and total protein in rats.
Boros in collaboration with Roche, the glycogen synthase activator GSA3 was administered to DIO mice (75 mg/kg), along with a stable isotope (non-emitting) glucose tracer.
Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS?
Fructose-1,6-bisphosphatase activity was measured by the method of Gancedo and Gancedo (1971), pyruvate kinase activity was estimated by the method of Pogson and Denton (1967), lactate dehydrogenase activity was estimated by the method of King (1965), glycogen synthase activity was estimated by the method of Leloir and Goldemberg (1962), glycogen phosphorylase activity was estimated by the method of Cornblath et al.
Glycogen synthase kinase 3 Beta (GSK3 Beta) is a serine/threonine kinase originally identified for its role in glycogen metabolims regulation.
The rogue signal, glycogen synthase kinase 3, was previously found to halt uncontrolled cell growth, preventing several forms of cancer.
The activities of hexokinase, glucose-6-phosphatase, fructose-1,6- bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase were measured.
In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.
Highlights include: - Lentivirus-Based siRNA Target Validation In Vivo: Potential Applications for Kinases Luk van Parijs, CENTER FOR CANCER RESEARCH -- MIT - Pharmacological Inhibitors of Cyclin-Dependent Kinases (CDKs) and Glycogen Synthase Kinase-3 (GSK-3) Laurent Meijer, THE ROCKEFELLER UNIVERSITY

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