glycogen synthase

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gly·co·gen syn·thase

, glycogen starch synthase
a glucosyltransferase catalyzing the incorporation of d-glucose from UDP-d-glucose into 1,4-α-d-glucosyl chains. A deficiency of the liver enzyme may lead to a type of hypoglycemia.


a polysaccharide, the chief carbohydrate storage material in animals. It is formed and stored in the liver and muscles (phosphorylytically cleaved to glucose-1-phosphate). Called also animal starch.

glycogen granules
electron-dense accumulation of glycogen molecules.
glycogen nephrosis
deposition of glycogen in the renal tubules in diabetes mellitus but without apparent effect on renal function.
glycogen phosphorylase
glycogen phosphorylase the major enzyme in glycogenolysis, leading to the release of glucose-1-phosphate from glycogen. This enzyme is activated by phosphorylation from ATP by glycogen phosphorylase kinase, activated by cAMP-dependent protein kinase or by Ca2+ via calmodulin, or inhibited by hydrolysis of the phosphate by glycogen phosphorylase phosphatase.
glycogen synthase
an enzyme in the glycogenesis process.
References in periodicals archive ?
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).
Glycogen synthesis was increased due to the deactivation of GSK-3[beta], which lies upstream of glycogen synthase (GS) (Bouskila et al.
2002) Glycogen synthase kinase 3/SHAGGY-like kinases in plants: an emerging family with novel functions.
Hemmings, "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B," Nature, vol.
Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3[beta]," American Journal of Physiology--Heart and Circulatory Physiology, vol.
The final product is ATP, which is a form of energy storage needed for cellular metabolism [10-15] This hypothesis would have two consequences on the one hand, degradation of glycogen phosphorylase activation or induction of glycogen as it is explained above, this reaction remained upstream of the cascade of biochemical reactions that lead to a complete glycolysis with the results in the formation of ATP, the other possible entry of glucose into hepatocytes through activation of glycogen synthase.
Seasonal variations of glycogen synthase and phosphorylase activities in the liver of the frog Rana esculenta.
Mechanism of activation of liver glycogen synthase by swelling.
Influence of fructose on the glycogen synthase and phosphorylase systems in rat liver.
2010) have recently shown that the treatment with 3NPA induced glycogen synthase kinase3b (GSK-3b) truncation that augmented its kinase activity.
An increase in post-exercise glycogen synthase and exercise-induced increases in insulin sensitivity may be the potential mechanism responsible for the 2- to 4-hour period of enhanced glycogen resynthesis following exercise.
The enzymes of glycogenolysis had little time to prepare For this sudden onslaught, they were on the brink of despair; The cells were loaded with glycogen; there was hardly any space; Glycogen Synthase and his friends seemed to be running a mad race.

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