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glycogen synthase

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson 0.03 sec.
glycogen synthase
n.
An enzyme that catalyzes the transfer of glucose from UDP-glucose to glycogen.

glycogen
a polysaccharide, the chief carbohydrate storage material in animals. It is formed and stored in the liver and muscles (phosphorylytically cleaved to glucose-1-phosphate). Called also animal starch.

glycogen granules
electron-dense accumulation of glycogen molecules.
glycogen nephrosis
deposition of glycogen in the renal tubules in diabetes mellitus but without apparent effect on renal function.
glycogen phosphorylase
glycogen phosphorylase the major enzyme in glycogenolysis, leading to the release of glucose-1-phosphate from glycogen. This enzyme is activated by phosphorylation from ATP by glycogen phosphorylase kinase, activated by cAMP-dependent protein kinase or by Ca2+ via calmodulin, or inhibited by hydrolysis of the phosphate by glycogen phosphorylase phosphatase.
glycogen synthase
an enzyme in the glycogenesis process.


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The researchers studied the proteins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) and amyloid beta (AEi) plaque, to quantitatively examine their roles in the development of Alzheimer's pathology.
Now, Li-Huei Tsai, professor of neuroscience at the MIT, and colleagues have shown for the first time that DISC1 directly inhibits the activity of a brain enzyme called glycogen synthase kinase 3 beta, responsible for schizophrenic conditions.
Researchers believe glycogen synthase kinase 3 (GSK3) could provide a new therapy, paving the way to new treatments.
 
 
 
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