glycogen phosphorylase


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Related to glycogen phosphorylase: glycogen synthase

phos·phor·y·lase

(fos-fōr'i-lās),
An enzyme cleaving poly(1,4-α-d-glucosyl)n with orthophosphate to form poly(1,4-α-d-glucosyl)n-1 and α-d-glucose 1-phosphate. The active form of the enzyme is a phosphorylated protein.

glycogen phosphorylase

/gly·co·gen phos·phor·y·lase/ (gli´ko-jen fos-for´ĭ-lās) see phosphorylase.

glycogen

a polysaccharide, the chief carbohydrate storage material in animals. It is formed and stored in the liver and muscles (phosphorylytically cleaved to glucose-1-phosphate). Called also animal starch.

glycogen granules
electron-dense accumulation of glycogen molecules.
glycogen nephrosis
deposition of glycogen in the renal tubules in diabetes mellitus but without apparent effect on renal function.
glycogen phosphorylase
glycogen phosphorylase the major enzyme in glycogenolysis, leading to the release of glucose-1-phosphate from glycogen. This enzyme is activated by phosphorylation from ATP by glycogen phosphorylase kinase, activated by cAMP-dependent protein kinase or by Ca2+ via calmodulin, or inhibited by hydrolysis of the phosphate by glycogen phosphorylase phosphatase.
glycogen synthase
an enzyme in the glycogenesis process.
References in periodicals archive ?
A significant decline in the glycogen level as well as in the glycogen synthase activity anda concomitant increase in the activity of glycogen phosphorylase were noted in the liver of diabetic rats.
Activity of glycogen phosphorylase (GP) and the content of glycogen in cytosolic fraction and the activities of isocitrate dehydrogenase (ICDH) and succinate dehydrogenase (SDH) in mitochondria liver and skeletal muscle of experimental animals Parameters CON FRU GP (A): Liver 4.
Glycogen phosphorylase is an enzyme that exists in two forms, one activated with adenosine mono phosphate (AMP) and the other activated without it, which are interconversible by phosphorylation and dephosphorylation mechanism (Cori and Cori 1945; Cori et al.
Immunoenzymometric assay of human glycogen phosphorylase isoenzyme BB in diagnosis of ischemic myocardial injury.
The assay of glycogen phosphorylase in human blood serum and its application to the diagnosis of myocardial infarction.
A significant decline in the glycogen level as well as in the glycogen synthase activity and a concomitant increase in the activity of glycogen phosphorylase were observed in the liver of diabetic rats.
Other product candidates include a glycogen phosphorylase inhibitor currently in a Phase I clinical trial and a glucokinase activator scheduled to enter clinical trials in 2005.
Glycogen is the primary intracellular storable form of glucose and its level in various tissues especially in liver and skeletal muscles indicates direct reflection of insulin activity since it regulates glycogen deposition by stimulating glycogen synthase and inhibiting glycogen phosphorylase.
Combinations of cardiac markers include Troponin I, Troponin T, glycogen phosphorylase, fatty acid binding proteins, carbonic anhydrase etc.
Catechin restored the altered Glucokinase, glucose-6 Phosphatase, Glycogen Synthase and Glycogen Phosphorylase levels to near normal.