glyceryl guaiacolate


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Related to glyceryl guaiacolate: terpin hydrate

guaifenesin (glyceryl guaiacolate)

Balminil Expectorant (CA), Benilyn Childrens Chesty Coughs (UK), Benylin-E (CA), Calmylin Expectorant (CA), Diabetic Tussin EX, Genatuss, Koffex Expectorant (CA), Mucinex, Organidin NR, Phanacin XPECT, Pneumomist, Resyl (CA), Robitussin, Robitussin Chesty Cough (UK), Scot-tussin Expectorant, Siltussin SA, Tixylix Chesty Cough (UK), Venos for Kids (UK), Vicks Vaposyrup for Chesty Coughs (UK)

Pharmacologic class: Propanediol derivative

Therapeutic class: Expectorant

Pregnancy risk category C

Action

Exerts vasoconstrictive action that leads to decreased edema and congestion. Also increases respiratory secretions and reduces mucus viscosity.

Availability

Capsules: 200 mg

Oral solution: 100 mg/5 ml, 200 mg/5 ml

Syrup: 100 mg/5 ml

Tablets: 100 mg, 200 mg, 400 mg

Tablets (extended-release): 600 mg

Indications and dosages

Cough due to upper respiratory tract infection

Adults: 200 to 400 mg P.O. q 4 hours (not to exceed 2,400 mg/day), or 600 to 1,200 mg P.O. (extended-release tablets) q 12 hours (not to exceed 2,400 mg/day)

Children ages 6 to 12: 100 to 200 mg P.O. q 4 hours (not to exceed 1,200 mg/day), or 600 mg P.O. (extended-release) q 12 hours (not to exceed 1,200 mg/day)

Children ages 2 to 6: 50 to 100 mg P.O. q 4 hours (not to exceed 600 mg/day)

Contraindications

• Hypersensitivity to drug
• Alcohol intolerance (with some products)

Precautions

Use cautiously in:
• diabetes mellitus, cough lasting more than 1 week or accompanied by fever, rash, or headache
• patients receiving disulfiram concurrently
• pregnant patients.

Administration

• Give with full glass of water.

Adverse reactions

CNS: headache, dizziness

GI: nausea, vomiting, diarrhea, stomach pain

Skin: rash, urticaria

Interactions

Drug-diagnostic tests.Urinary 5-hydroxyindoleacetic acid, vanillylmandelic acid: inaccurate results

Patient monitoring

• Assess cough quality and productivity. Reevaluate treatment if cough persists and is accompanied by fever or headache.

Patient teaching

• Tell patient to take with 8 oz of water and to drink plenty of fluids.
• Instruct patient to contact prescriber if cough lasts more than 1 week.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

guai·fen·e·sin

(gwī-fen'ĕ-sin),
An expectorant that allegedly reduces the viscosity of sputum, thus facilitating its elimination.

glyceryl guaiacolate

glyceryl

the mono-, di- or trivalent radical formed by the removal of hydrogen from one, two or three of the hydroxy groups of glycerol.

glyceryl guaiacolate
a centrally acting muscle relaxant very popular as an additive in anesthesia, especially in horses.
glyceryl trinitrate
glyceryl trioleate
see olein.