This collaboration between Agilent and BTI addresses a critical need in the biopharmaceutical industry for a novel technology platform that can support detailed glycan
analysis quickly and effectively in a high throughput environment," said Nino Totino, general manager for Agilent's Life Sciences and Applied Markets Group in the South Asia, Pacific and Korea region.
Matthew Macauley, a senior research associate in Paulson's group, and colleagues treated the animals with tiny nanoparticles that included both Factor VIII and the glycan
that binds with CD22.
Scientists are attempting to develop production and processing models that recognize the intrinsic biological value of food byproducts and sidestreams, which may contain these glycans
This research initiative enables scientists to optimize glycan
analytical workflows on the Agilent HPLC-Chip/MS system,' said Dr.
Scientists can study glycosylated proteins by breaking apart cells, then using agarose beads coated with hydrazide molecules to attract the glycans
and therefore their associated proteins.
Until recently, the study of glycoproteins by mass spectrometry has been based on the cleavage of glycans
followed by separate analysis of glycans
and deglycosylated proteins, which limits the ability to derive glycan
compositions for individual glycoproteins.
The cream tricks the skin into regeneration by boosting its sugar levels, also known as glycans
, which play a critical role in improving your skin's health.
ProtAffin AG, a biotechnology company developing a novel class of biopharmaceutical products that act by targeting cell-surface glycan
structures, today announced it has signed a manufacturing contract with CMC Biologics Danish operations, located in Copenhagen, Denmark for manufacture of its lead product PA401 for the treatment of chronic obstructive pulmonary disease (COPD).
Researchers working in biology, biotechnology, biophysics, cancer research, pathology and laboratory medicine, immunology, and other areas around the world cover current approaches to assessing lectin functions, including structural and thermodynamic approaches to study lectin-ligand interactions; the use of glycan
arrays to identify lectin ligands and the qualitative and quantitative analyses of their interactions; whole-genome analysis to characterize the molecular, structural, and evolutionary diversity of lectins; and animal models for assessing their biological roles.
The heparinlike compound is similar to the heparin glycan
, which comes from pig intestine.
The MIT study shows that this view does not adequately explain 1) how viruses evolve to infect humans, and, more specifically, 2) the ability of a flu virus to bind to a certain shape, or topology, of specific alpha 2-6 glycan
receptor, which determines whether it will infect humans.
But recent advances in technologies such as the development of glycan
arrays have made the initiative feasible.