gluten enteropathy


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Related to gluten enteropathy: celiac disease

enteropathy

 [en″ter-op´ah-the]
any disease of the intestine.
gluten enteropathy (gluten sensitive enteropathy) celiac disease.
protein-losing enteropathy a nonspecific term referring to conditions, e.g., adult celiac disease, associated with excessive loss of enteric plasma proteins.

ce·li·ac dis·ease

[MIM*212750]
a disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, nutritional and vitamin deficiencies, and failure to thrive, or short stature.

coeliac disease

A malabsorptive syndrome caused by hypersensitivity of intestinal mucosa to alpha-gliadin, a gluten extract composed of glutamine and proline-rich proteins that is found in wheat, barley, rye, and oats.
 
Clinical findings
Diarrhoea, copious fatty stools, abdominal distension, weight loss, haemorrhage, osteopenia, muscle atrophy, peripheral neuropathy, CNS and spinal cord demyelination (sensory loss, ataxia), amenorrhoea, infertility, oedema, petechiae, dermatitis herpetiformis (especially if HLA B27), alopecia areata. Occult bleeding occurs in half of patients.
 
Lab
Transaminases (ALT, AST) are increased in ± 40% of patients with CD, which usually normalises with a gluten-free diet; iron deficiency, anaemia due to occult bleeding.

Diagnosis
Duodenal biopsy; anti-gliadin and anti-endomysial antibodies.
 
Management
Eliminate gliadin from diet.

Prognosis
Without treatment, 10–15% develop lymphoma (e.g., immunoblastic lymphoma; less commonly, T cell lymphoma), a risk that increases with disease duration. CD predisposes to gastrointestinal lymphoma and carcinoma of the oral cavity and oesophagus; the otherwise rare small intestinal adenocarcinoma is 80-fold more common in CD.

gluten enteropathy

Celiac sprue, gluten-sensitive enteropathy A condition characterized by malabsorption of nutrients through the small intestine due to an immune reaction to gluten, a protein in wheat or related grains and other foods Clinical Diarrhea, weight loss, which may be associated with dermatitis herpetiformis Diagnosis Bx of involved small bowel Management Gluten-free diet, see there.

ce·li·ac dis·ease

(sē'lē-ak di-zēz')
A disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, and nutritional and vitamin deficiencies.
Synonym(s): gluten enteropathy, coeliac disease.

Gluten enteropathy

A hereditary malabsorption disorder caused by sensitivity to gluten, a protein found in wheat, rye, barley, and oats. Also called non-tropical sprue or celiac disease.

gluten enteropathy,

n See disease, celiac.

ce·li·ac dis·ease

(sē'lē-ak di-zēz') [MIM*212750]
A disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine.
Synonym(s): gluten enteropathy, coeliac disease.

enteropathy

any disease of the intestine. Includes enteritis plus those diseases in which there is no physical lesion of enteritis but in which there is severe diarrhea.

cystic mucinous enteropathy
see lymphocytic-plasmacytic enteritis.
gluten enteropathy
celiac disease. See wheat-sensitive enteropathy (below).
mucoid enteropathy
a secretory diarrhea of rabbits, of unknown cause; characterized by occurrence of mucoid diarrhea, abdominal distention, cecal impaction, constipation, depression and hypothermia in rabbits of weaning age and older.
mycotic enteropathy
one caused by a fungal agent; see histoplasmosis, phycomycosis, candidiasis.
porcine proliferative enteropathy
see proliferative hemorrhagic enteropathy.
protein-losing enteropathy (PLE)
a nonspecific term referring to conditions associated with excessive loss of plasma proteins into the intestinal lumen. Associated with a variety of systemic and bowel disorders, including congestive heart failure, gastric ulceration, gastric tumors, intestinal mucosal ulceration and lymphatic disorders, intestinal parasitic infestations, bacterial induced lesions such as in Johne's disease and the proliferative enteropathies.
rabbit enteropathy complex
term used to designate a number of poorly defined diarrheal conditions of rabbits; includes mucoid enteropathy and nonspecific enteropathy.
wheat-sensitive enteropathy
a hereditary sensitivity to gluten, seen in Irish setters. There is diarrhea and poor growth in young dogs.

Patient discussion about gluten enteropathy

Q. Is celiac genetic? I have one son with celiac disease from my first marriage and me second wife is now pregnant,I was wondering what are the chances for this soon to be born daughter of mine to have celiac as well- if I maybe carry the genetic flaw and is there a way to find out?

A. Celiac disease is a very common illness (about 1 in a 100 people suffer from it in different levels), and it is known to have a strong genetic connection. However, there is not one specific mutation that you can get genetic testing to see if you are carrying it. Your soon to be born daughter will have a higher chance than the regular population to suffer from the disease, but it does not necessarily mean she will.

Q. How do you diagnose celiac? My daughter is 3 years old and is constantly vomiting, has diarrhea and stomach aches. Could this be celiac?

A. This could in fact be celiac. The initial step in screening should include: IgA endomysial antibodies (EMA), IgA tissue transglutaminase (tTG), IgG tissue transglutaminase and Total IgA antibodies. The patients with positive antibody tests, and those with an IgA deficiency, should have a small bowel biopsy to confirm the diagnosis and assess the degree of damage, which is performed endoscopically (looking inside the body by inserting a tube into it).

Q. Is FTT a symptom of celiac? My 1.5 year old son has FTT (failure to thrive) and stomach aches. What could be causing it?

A. Failure to thrive lacks a precise definition, in part because it describes a condition rather than a specific disease. Children who fail to thrive don't receive or are unable to take in, retain, or utilize the calories needed to gain weight and grow as expected. FTT can be caused from many different things: social factors, conditions involving the gastrointestinal system like gastroesophageal reflux, chronic diarrhea, cystic fibrosis, chronic liver disease, and celiac disease. From a chronic illness or medical disorder, an intolerance of milk protein, infections or metabolic disorders.

More discussions about gluten enteropathy