glutathione peroxidase

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Related to glutathione peroxidase: Glutathione reductase

glu·ta·thi·one per·ox·i·dase

an enzyme that catalyzes the reaction of two glutathiones with H2O2, forming glutathione disulfide and two water molecules; a crucial enzyme in hydrogen peroxide detoxification.

glutathione peroxidase

An antioxidant enzyme found in many mammalian cells, including red blood cells. Deficiencies of the enzyme have been linked to an increased risk of acute coronary syndrome.


reduced glutathione (GSH), a tripeptide containing glutamic acid, cysteine and glycine, which serves as a reducing agent in many biochemical reactions, being converted to oxidized glutathione (GSSG) in which the cysteine residues of two glutathione molecules are connected by a disulfide bridge. Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis; deficiency causes sensitivity to oxidant drugs.

glutathione peroxidase
a selenium-containing enzyme whose blood level is a good indicator of the selenium status of the animal; occurs in a plasma form, an enzyme with specificity for phospholipids, and an intracellular form. Called also GPx.
glutathione reductase
a flavin enzyme involved in the defense of the erythrocyte against hemolysis. A partial deficiency occurs relatively frequently but is due to a deficiency of riboflavin; called also GR.
References in periodicals archive ?
Alterations in the antioxidant enzymes activities such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), the three primary scavenging enzymes, have been demonstrated in different tissues of diabetic animals (Kakkar et al.
CRP (an inflammation marker) and cortisol (indicative of stress and fatigue) levels and glutathione peroxidase (indicative of oxidative stress) activity also increased in blood serum after the competition, suggesting that stress had occurred.
Glutathione peroxidase (GPx) and catalase (CAT) then independently convert [H.
A sensitive fluorimetric microassay for the determination of glutathione peroxidase activity.
Characteristics of human milk glutathione peroxidase.
Glutathione peroxidase catalyzes the breakdown of inorganic and organic peroxides and prevents lipid peroxidation and protects the cell membrane from oxidative damage (33).
Distribution of selenium and glutathione peroxidase in blood fractions from humans, rhesus and squirrel monkeys, rats and sheep.
Selenium-dependent glutathione peroxidase (GSH-PX1) activity (as enzyme unit per milligram of hemoglobin) in blood was assayed with the method of Paglia and Valentine (1967).
The oxidative aggression suffered by the neonate is counteracted by maturation of effective antioxidant mechanisms such as the enzymatic systems (superoxide dismutase, catalase, glutathione peroxidase, etc.
Myocardial SOD and glutathione peroxidase activity were decreased and lipid peroxidation was increased.
By mimicking glutathione peroxidase (GPx), ALT-2074 may protect against excessive oxidation of lipids and thereby limit inflammation.

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