glutathione S-transferase


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glu·ta·thi·one S-·trans·fer·ase

a class of enzymes that catalyzes the reaction of glutathione with an acceptor molecule (for example, an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.
Synonym(s): ligandin
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References in periodicals archive ?
Relationship between glutathione S-transferase, catalase, oxygen consumption, lipid peroxidation and oxidative stress in eggs and larvae of Boophilus microplus (Acarina: Ixodidae).
The gene provides the building instructions for making an enzyme called glutathione S-transferase.
Enter the GST gene, which codes for an enzyme called glutathione S-transferase.
Townsend's second poster includes data showing that S-glutathionylation of some proteins after treatment of transformed human cells with NOV-002 (in this poster GSSG) may require the activity of glutathione S-transferase pi, which is known to be elevated in many types of human tumors.
4) Some are genetic, as occurs in the case of glutathione S-transferase gene variations that boost sensitivity to air pollutants.
Gene Gene name US patent symbol MGST3 Microsomal glutathione S-transferase 3 5,919,627 GBP1 Guanylate binding protein 1, interferon- 6,894,157 inducible, 67kDa GGH Gamma-glutamyl hydrolase (conjugase, 5,801,031 folylpolygammaglutamyl hydrolase) MTAP Methylthioadenosine phosphorylase 5,942,393; 6,870,037 MADCAM1 Mucosal vascular addressin cell adhesion 7,750,137 molecule 1 POSTN Periostin, osteoblast specific factor 6,518,063 PMS1 PMS1 postmeiotic segregation increased 1 5,922,855; (S.
P-glycoprotein, glutathione and glutathione S-transferase increase in a colon carcinoma cell line by colchicine.
ADT increases production of the enzyme glutathione S-transferase (GST).
Telintra has a novel mechanism of action that inhibits an enzyme called glutathione S-transferase P1-1, which leads to activation of Jun kinase, a key regulator of cellular growth and differentiation of blood precursor cells; this mechanism induces cancer cell death, or apoptosis, in human leukemia cell lines.
We conducted a study to determine whether N-Acetyl-cysteine (NAC) protected men against noise-induced temporary threshold shift (TTS), and whether subgroups with genetic polymorphisms of glutathione S-transferase (GST) T1 and M1 responded to NAC differently.
Additionally, experiments were conducted to quantify changes in feeding behavior and changes in the expression levels of general esterase, glutathione S-transferase, and cytochrome P450 of D.
Genetic polymorphisms in glutathione S-transferase (GST) superfamily and arsenic metabolism in residents of the Red River Delta, Vietnam.