glutamine synthetase

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Related to glutamine synthetase: glutaminase, glutamate synthase

glu·ta·mine syn·the·tase

an enzyme that catalyzes the reaction of l-glutamate, ammonia, and ATP to glutamine, ADP, and orthophosphate; one of the few known mammalian enzymes that uses ammonium ion as a substrate under physiologic conditions.


An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.


Gln; an amide of glutamic acid, an amino acid occurring in proteins; it is an important carrier of ammonia to the kidney where it is released by glutaminase.

glutamine synthetase
enzyme catalyzing the synthesis of the amino acid, glutamine from glutamate ammonia and ATP. Major means of detoxifying ammonia from amino acid catabolism in peripheral tissues and then transporting the ammonia as the amido-N in glutamine to the liver of kidney.
References in periodicals archive ?
Complementary distribution of carbamoylphosphate synthetase (ammonia) and glutamine synthetase in rat liver acinus is regulated at a pretranslational level.
Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease.
glutamine synthetase inhibitor, which process comprises transforming cells
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7,101,680 "Method for detecting the presence of monomeric brain associated human glutamine synthetase," relates to a method for detecting a biochemical marker, human glutamine synthetase, by immunoassay as a potential diagnostic for Alzheimer's disease.
The AD technology for human in vitro diagnostic applications using glutamine synthetase as a marker was exclusively licensed to Ortho last October.
Nexus Dx(TM) for Alzheimer's disease is a proprietary rapid in vitro diagnostic test for the determination of glutamine synthetase (GS) in human whole blood.

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