GLUL

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GLUL

An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.
References in periodicals archive ?
suggested that endophyte infected grasses represent greater activity of glutamine synthase, that is responsible for synthesis of glutamine in plant roots and thereby, the higher activity of L-glutaminase in the rhizosphere of E+ plants can be possibly attributed to higher concentration of the L-glutamine that is excreted into the rhizosphere and consequently induced higher levels of L-glutaminase activity.
The results also demonstrated that glutamine synthase and the N-methyl-D-aspartate receptor subunits are key targets for superoxide mediated nitration and subsequent inactivation in this pathway.
Cyclic adenosine-3',5'-monophosphate-mediated activation of a glutamine synthase composite glucocorticoid response element.

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