glutaminase


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glutaminase

 [gloo-tam´ĭ-nās]
an enzyme that catalyzes the splitting of glutamine into glutamic acid and ammonia.

glu·ta·min·ase

(glū-tam'in-ās),
An enzyme in kidney and other tissues that catalyzes the hydrolysis of l-glutamine to ammonia and l-glutamate; an important enzyme in urinary ammonia formation.

glutaminase

/glu·tam·i·nase/ (gloo-tam´ĭ-nās) an enzyme that catalyzes the deamination of glutamine to form glutamate and an ammonium ion; most of the latter are converted to urea via the urea cycle.

glu·ta·min·ase

(glū-tam'in-ās)
An enzyme in kidney and other tissues that catalyzes the hydrolysis of l-glutamine to ammonia and l-glutamic acid; an important enzyme for urinary ammonia formation.

glutaminase

an enzyme that hydrolyzes the splitting of glutamine into glutamate and ammonia.
References in periodicals archive ?
CB-839 is a potent and selective orally bioavailable glutaminase inhibitor that blocks the growth and survival of many different types of cancer cells by interfering with the metabolism of glutamine.
This enzyme is an exopeptidase with endopeptidase and glutaminase side activities.
Glutamate is an excitatory amino acid found in all foods containing protein that is synthesized from glutamine by the enzyme glutaminase.
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
The glutaminase activity of BNT asparaginase was determined as the two activities were commonly found on the same protein [16,17].
Now, they have discovered a molecule that does the job: Dubbed 968 by investigators, this proof of concept molecule binds to the enzyme glutaminase to inhibit cancer growth by blocking the cancer cells' utilization of glutamine.
Glutaminase in the presynaptic terminals of neurons converts glutamine to glutamate.
O fígado, órgão envolvido no controle da homeostase no organismo, é responsável por ajustar os níveis plasmáticos de glutamina aos valores fisiológicos, por possuir alta atividade das enzimas glutamina sintetase e glutaminase.
Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal hepatocytes.
Ammonia excretion and renal glutaminase activity during administration of strong acid and buffer acid.
In the glial cells, glutamate is converted to glutamine by the enzyme glutamine synthetase and returned to the presynaptic neuron where glutaminase converts glutamine back to glutamate (Laake, Slyngstad, Haug, & Ottersen, 1995).
GLUTAMINASE EXPRESSION IN A TRANSFECTANT RAT PROXIMAL TUBULE CELL LINE.

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