Antiphospholipid and glutamic acid decarboxylase
antibodies in patients with focal epilepsy.
The clinical significance of an autoimmune response against glutamic acid decarboxylase
UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase
for prediction of insulin requirement in type 2 diabetes.
Glutamic acid decarboxylase
in Parkinson's disease and epilepsy.
Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase
and islet antigen-2.
Islet cell antibodies and glutamic acid decarboxylase
antibodies but not the clinical phenotype help to identify type 1V2 diabetes in patients presenting with type 2 diabetes.
Titre and combination of ICA and autoanti-bodies to glutamic acid decarboxylase
discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA).
In 41 infants who had a parent or sibling with type 1 diabetes, significant increases in rotavirus antibodies coincided with the first appearance of insulin autoantibodies in 19 of 23, with antibodies to glutamic acid decarboxylase
(GAD) in 14 of 20, and with IA-2 antibodies in 14 of 21 at-risk infants.
GABA is made by a gene called glutamic acid decarboxylase
, or GAD.
It now seems that the appearance of autoantibodies to beta-cell antigens, such as those against the 65-kDA isoform of glutamic acid decarboxylase
(GAD65)  and the protein tyrosine phosphatase-like insulinoma associated protein 2 (IA-2) in the peripheral circulation is a predictive sign of clinical disease.
Initially, diabetes-associated autoantibodies were detected by immunofluorescence staining of pancreatic islets, but several autoantibodies can now be detected at the molecular level in serum samples, the most important autoantigens being the 65-kDa isoform of glutamic acid decarboxylase
(GAD65), protein tyrosine phosphatase-like protein (IA-2), and insulin (4).
The loss of [beta] cells is associated with multiple immunopathologic phenomena, best reflected by the appearance of autoantibodies to one or more of the following islet autoantigens: the 65-kDa isoform of glutamic acid decarboxylase
(GAD), an insulinoma antigen-2 (IA-2 or ICA512), or insulin itself (8).