glutamic acid decarboxylase


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.
Related to glutamic acid decarboxylase: Glutamic Acid Decarboxylase Antibody, GAD65

glutamic acid decarboxylase

Abbreviation: GAD
An enzyme (molecular mass 65 kD) that is found in the brain and the islet cells of the pancreas and participates in the synthesis of gamma-aminobutyric acid. Antibodies to GAD are found in the blood of patients with diabetes mellitus, type, and stiff-person syndrome.
See also: decarboxylase
References in periodicals archive ?
The clinical significance of an autoimmune response against glutamic acid decarboxylase.
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Possible implication of an inosinetriphosphate metabolic error and glutamic acid decarboxylase in paranoid schizophrenia.
Fusion proteins for combined analysis of autoantibodies to the 65-kDa isoform of glutamic acid decarboxylase and islet antigen-2 in insulin-dependent diabetes mellitus.
Radioimmunoprecipitation assay for glutamic acid decarboxylase antibodies evaluated clinically with sera from patients with insulin-dependent diabetes mellitus.
Identifcation of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody positivity at onset predicts diabetes type.
The antigens reactive in the ICA assay were unknown until 1990, when glutamic acid decarboxylase 65 (GAD 65) antibodies (GADA) were discovered as another autoimmune marker of IDDM [2].
The patent covers a glutamic acid decarboxylase (GAD)-based delivery system for use in gene therapy of the brain to treat Parkinson's disease, which is the technology that is being used in our sponsored Phase I trial for Parkinson's disease, and solidifies our position as the world's leading innovator in gene therapy of the brain and central nervous system.
More specifically, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalamic nucleus, which is a key component of the circuit that regulates movement.

Full browser ?