glutamatergic


Also found in: Dictionary, Thesaurus, Encyclopedia.

glutamatergic

(glū'tă-mă-tĕr'jik),
Pertaining to the action of glutamate or to neural or metabolic pathways in which it functions as a transmitter.
[glutamate + G. ergon, work]
References in periodicals archive ?
The stem cell researchers could prove this by means of a specific transcription factor: Tbr2 is only present in progenitor cells of glutamatergic nerve cells.
Actions of TNF-alphaalpha on glutamatergic synaptic transmission in the central nervous system.
Molecular changes in glutamatergic synapses induced by [Pb.
Nevertheless, the study suggests that limiting alcohol use might help control glutamatergic regulation and prove critical, Ms.
Preclinical data and clinical studies performed at Yale, as well as at other academic centers, suggest that the glutamatergic system is a truly viable target for neuropsychiatric drug development," says Dr.
The endocannabinoid N-arachidonoyl-dopamine (NADA) is able to both, increase the glutamatergic transmission to dopaminergic neurons by binding to the vanilloid receptor 1, and decrease it by binding to the CB1 receptor.
For example, exciting emerging evidence suggests that alcohol effects are altered in mice carrying various mutations of the glutamatergic genes (see review by Gass and Olive 2008).
Safinamide is believed to have a novel dual mechanism of action based on the enhancement of the dopaminergic function (through potent, reversible inhibition of monoamine oxidase-B [MAO-B], and dopamine uptake) and reduction of glutamatergic activity by inhibiting glutamate release.
April 2011: Announced receipt of a notice of allowance from the US PTO for the patent "Di-Substituted Amides for Enhancing Glutamatergic Synaptic Responses," which provides patent protection into the year 2028 for Cortex's lead compound, CX1739, and approximately 80 other AMPAKINE compounds.
Taken together, these data suggested that (--)-linalool was able to impair the acquisition of memory in rats, which can be associated to (--)-linalool antagonist capacity as regards NMDA glutamatergic receptors, since other glutamate antagonists also seem to affect memory.
The glutamatergic N-methyl-D-aspartate (NMDA) receptor is critically involved in learning and memory, and this learning might be augmented by the NMDA partial agonist DCS.

Full browser ?