GRIA4

(redirected from glutamate receptor 4)

GRIA4

A gene on chromosome 11q22 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Molecular pathology
Weak data have linked GRIA4 mutations to schizophrenia.
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Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl) phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu (4)) with oral efficacy in an antiparkinsonian animal model.
PXT002331, which was found to be safe and well tolerated, targets the metabotropic glutamate receptor 4.
5 September 2011 - Swiss biopharmaceutical company Addex Pharmaceuticals (SWF:ADXN) said on Friday that the company would get back all rights to metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM) programme from US pharmaceutical company Merck & Co Inc (NYSE:MRK).
The collaboration is focused on developing positive allosteric modulators (PAM) of the metabotropic glutamate receptor 4 (mGluR4) for the treatment of Parkinson's disease and other undisclosed indications.

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