GRIA1

(redirected from glutamate receptor 1)

GRIA1

A gene on chromosome 5q33 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.
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According to the company, the glutamate receptors, in particular the metabotropic glutamate receptor 1 (GRM1), are expressed on several tumors and plays a critical role in tumor metabolism.
Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus.
2012) Glutamate receptor [delta]2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase C.
Thus, of the AMPA family of glutamate receptors, knock-out mice lacking the glutamate receptor 1 subunit (GluR1) exhibited notably reduced aggressive behavior in a variety of agonistic paradigms, indicating that signaling through glutamate receptors expressing this subunit may play an important role in aggression (Vekovischeva et al.
A team led by Roberto Malinow of Cold Spring Harbor Laboratory in New York traced the hormone's effects to a receptor molecule called glutamate receptor 1 (G1uR1) on the surfaces of nerve cells.
Augmented motor activity and reduced striatal preprodynorphin mRNA induction in response to acute amphetamine administration in metabotropic glutamate receptor 1 knockout mice.

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