glutamate receptor


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glutamate receptor

Any of a family of heteromeric protein complexes that are the primary excitatory neurotransmitter receptors in the brain, which are activated by various neurophysiologic stimuli. Glutamate receptors are comprised of multiple subunits, each with transmembrane regions, and form a ligand-gated ion channel. They are classified based on their activation by different pharmacologic agonists.
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Gria2 codes for a subunit of the alpha-amino-3-hydroxy-5-methy1-4-isoxazolepropionic acid (AMPA)-receptors, which belong to the group of glutamate receptors.
Analyses of these effects of alcohol consumption and withdrawal on the glutamate system have led to the development of the medication acamprosate, which is a partial agonist of the NMDA receptor and an antagonist of metabotropic glutamate receptors (de Witte et al.
The team, led by Shogo Ishiuchi, a teaching assistant at Gunma University's Department of Neurosurgery, examined the role of calcium-permeable glutamate receptors on cells of glioblastoma and found that making them calcium-impermeable inhibited tumor cell migration, according to the study.
These findings indicate that increased expression of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms.
Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior.
This chemical attaches to the inside of a clamshell-shaped part of the glutamate receptor, a protein on the surface of nerve cells.
Augmented motor activity and reduced striatal preprodynorphin mRNA induction in response to acute amphetamine administration in metabotropic glutamate receptor 1 knockout mice.
Heptares Therapeutics, the leading GPCR structure-guided drug discovery and development company, announces the publication of a scientific article describing the first high-resolution X-ray crystal structure of the transmembrane domain of the metabotropic glutamate receptor 5 (mGlu5).
An impairment in the ability to correctly remember a familiar object signifies some disturbance in the signaling ability of the glutamate receptor in the prefrontal cortex, the brain region that controls working memory, attention, decision-making, emotion and other high-level "executive" processes.
Low doses of non-NMDA glutamate receptor agonists alter neurobehavioural development in the rat.
The lead author's laboratory studied the effects of a broad-spectrum glutamate receptor antagonist, kynurenic acid (KYNA), on glutamate- and noise-induced trauma in guinea pigs.

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