glutamate receptor


Also found in: Acronyms, Wikipedia.

glutamate receptor

Any of a family of heteromeric protein complexes that are the primary excitatory neurotransmitter receptors in the brain, which are activated by various neurophysiologic stimuli. Glutamate receptors are comprised of multiple subunits, each with transmembrane regions, and form a ligand-gated ion channel. They are classified based on their activation by different pharmacologic agonists.
References in periodicals archive ?
Therapeutic potential of metabotropic glutamate receptor modulators.
Since the CT-[beta]CD was able to produce anti-hyperalgesic effect in this model, we decided to investigate the possibility of interaction between the CT and ionotropic glutamate receptor (GluR2-SlS2J).
The report provides a snapshot of the global therapeutic landscape for Metabotropic Glutamate Receptor 3 (mGluR3 or GRM3 or GPRC1C or MGLUR3)
In addition to blocking excitatory stimuli at glutamate receptors in the brain, L-theanine also stimulates production of the inhibitory, relaxing neurotransmitter GABA, adding to its calming, anti-anxiety effects.
Another interesting molecule involved in LTD is glutamate receptor [delta]2 subunit (GluD2), an ionotropic glutamate receptor-related molecule which is specifically expressed on the postsynaptic membrane at parallel fiber-Purkinje cell synapses.
AMPA glutamate receptor subunits are differentially distributed in rat brain.
For example, both an antagonist of metabotropic glutamate receptor 5 (mGluR5) and agonists of mGluR2 and mGluR3, all of which decrease glutamate function, blocked cue-induced reinstatement of alcohol self-administration (Schroeder et al.
Thus, of the AMPA family of glutamate receptors, knock-out mice lacking the glutamate receptor 1 subunit (GluR1) exhibited notably reduced aggressive behavior in a variety of agonistic paradigms, indicating that signaling through glutamate receptors expressing this subunit may play an important role in aggression (Vekovischeva et al.
Several important proteins belong to the membrane protein group from which we have chosen the ionotropic glutamate receptor activated by N-methyl-D-aspartate as the subject of our work.
A drug that targets the gene Bear's team studied, which makes a protein called metabotropic glutamate receptor 5 (mGluR5), might be able to restore some mental functioning by improving this signaling, he says.
While topiramate's mechanism of action in BED is unknown, the investigators speculated that the antiseizure medication curbs appetite and enhances satiety through glutamate receptor antagonism.

Full browser ?