glucuronide


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glucuronide

 [gloo-ku´ron-īd]
any glycosidic compound of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols, and carboxylic acids.

glu·cu·ro·nide

(glū-kū'rōn-īd),
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (for example, steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.
Synonym(s): glucuronoside

glucuronide

/glu·cu·ron·ide/ (gloo-ku´ron-īd) any glycosidic compound of glucuronic acid; they are common soluble conjugates formed as a step in the metabolism and excretion of many toxins and drugs, such as phenols and alcohols.

glu·cu·ro·nide

(glū-kyūr'ō-nīd)
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (e.g., steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.

glucuronide

any glycosidic conjugate of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols and carboxylic acids.
References in periodicals archive ?
SafePlan(TM) is a simple and rapid (five-minute) urine test that measures the hormone metabolite pregnanediol glucuronide (PDG).
Ethyl glucuronide (EtG), another specialty test, is also a popular option.
Glucuronide formation facilitates excretion, but cannabinoid glucuronide pharmacological activity and detection windows following cannabis smoking are unknown, although these metabolites have been hypothesized to be markers of recent (10) or frequent (11) use.
Most BPA was found in the urine as the glucuronide conjugate.
SafePlan(TM) is designed to measure the hormone metabolite pregnanediol glucuronide (PDG) and indicate the safest time to have intercourse without becoming pregnant.
Services include drugs of abuse urine and oral fluid testing, ethyl glucuronide (EtG) testing and steroid testing.
Metabolism of DEHP involves hydrolysis to mono(2-ethylhexyl) phthalate (MEHP) and formation of a glucuronide MEHP conjugate.
Ezetimibe After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide (ezetimibe-glucuronide).
Mean plasma concentrations, Effect on ER/affinity Compounds nmol/L for ER (estradiol = 100%) Tamoxifen 190-420 Weak antagonist/2% (b) N-Desmethyltamoxifen 280-800 Weak antagonist/1% (b) N,N-Didesmethyltamoxifen 90-120 Weak antagonist Endoxifen 14-130 Strong antagonist/ equal to 4-hydroxytamoxifen 4-Hydroxytamoxifen 3-17 (C) Strong antagonist/ 188% (b) [alpha]-Hydroxytamoxifen 1 None 3,4-Dihydroxytamoxifen No data available Weak antagonist/high affinity Tamoxifen-N-oxide 15-24 Weak antagonist (d) 4-Hydroxytamoxifen-O- glucuronide No data available No antagonist (e) 4-Hydroxytamoxifen- [N.
The latter structure, as well as that of a dehydrated glucuronide conjugate of BPA (a major metabolite isolated from the digestive tract), showed that BPA metabolic routes were far more complex than previously thought.
Mycophenolic acid glucuronide was a gift from Roche Bioscience or was purchased from Analytical Services International.