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glucuronide

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glucuronide /glu·cu·ron·ide/ (gloo-ku´ron-īd) any glycosidic compound of glucuronic acid; they are common soluble conjugates formed as a step in the metabolism and excretion of many toxins and drugs, such as phenols and alcohols.
glu·cu·ro·nide (gl-kyr-nd)
n.
Any of various derivatives of glucuronic acid that often combine with toxic organic compounds and are excreted.

glucuronide [gloo-ku´ron-īd]
any glycosidic compound of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols, and carboxylic acids.

glucuronide
any glycosidic conjugate of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols and carboxylic acids.


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Human experimental studies of bisphenol A (BPA) metabolism have reported rapid clearance of the hormonally active parent compound via glucuronide conjugation followed by urinary excretion of the inactive conjugated metabolite.
Instead of being excreted via the gut, the metabolites may be hydrolysed by enzymatic activity of the gut bacteria (principally Clostridium species) to liberate active ethinyloestradiol from the sulphate and glucuronide groups.
Figure 4 shows extracted ion chromatograms (XIC) that were generated relating to the ketone glucuronide (m/z 411), glucuronide (m/z 381) and hydroxyglucuronide (m/z 397) metabolites.
 
 
 
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