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glucuronidation |
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glucuronidation (glōō·k  ·rō·n·dāˑ·shn),n a phase II detoxification pathway occurring in the liver in which glucuronic acid is conjugated with toxins. Effectively detoxifies the majority of commonly prescribed drugs. |
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Further, xenobiotics can induce steroid-metabolizing enzymes, including steroid sulfotransferases, steroid glucuronidation enzymes, and steroid hydroxylases (You 2004). Coadministration of gemfibrozil (600 mg twice daily for 3 days) with simvastatin (40 mg daily) resulted in clinically significant increases in simvastatin acid AUC (185%) and Cmax (112%), possibly due to inhibition of simvastatin acid glucuronidation by gemfibrozil (see WARNINGS, Myopathy/Rhabdomyolysis, PRECAUTIONS, Drug Interactions, DOSAGE AND ADMINISTRATION). Glucuronidation patterns of common urinary and serum monoester phthalate metabolites. |
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glucuronidation
