MRP1 demonstrated a substrate preference for negatively charged substrates, such as glutathione, glucuronate
, and sulfate conjugates, suggesting its role in maintaining cell redox state.
There are no major age-related differences in the overall rate of elimination of acetaminophen, but there are important differences in glucuronate
and sulfate conjugates.
A natural complex sugar of the glycosaminoglycan family, hyaluronan is a high molecular weight polysaccharide composed of repeating disaccharide units of sodium glucuronate
Enzymatic treatment of human plasma samples found that EGCG is minimally conjugated to glucuronate
or sulfate, however, EGC and EC were found to be extensively glucuronidated or sulfated (Chow et al.
5%) is conjugated with glucuronic acid to form a nonvolatile, water-soluble metabolite called ethyl glucuronate
Aldosterone, cholesterol, cortisone, cortisol, danazol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, estradiol, estradiol glucuronate
, estriol, estrone, progesterone, corticosterone, testosterone, norethindrone, pregnenolone sulfate, 11-deoxycortisol, 17[alpha]-hydroxypregnenolone, and 17[alpha]-hydroxyprogesterone at concentrations of [10.
In contranst to P-gp, MRP-1 is primarily an active transporter of GSH, oxidized GSH, glucuronate
and sulfate conjugated organic anions (Borst et al.
both conjugated and unconjugated) metanephrine and normetanephrine, sulfate and glucuronate
conjugates were firstly acid hydrolyzed such that all metanephrines were in their free form before acylation.