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glucuronic acid

a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is important in the conjugation of xenobiotics; it is conjugated to many poisons and drugs by the liver, forming glucuronides, which markedly decreases their toxicity and enhances their excretion by the liver, intestine, and kidney.


A salt or ester of glucuronic acid.


A salt or ester of glucuronic acid.
References in periodicals archive ?
MRP1 demonstrated a substrate preference for negatively charged substrates, such as glutathione, glucuronate, and sulfate conjugates, suggesting its role in maintaining cell redox state.
There are no major age-related differences in the overall rate of elimination of acetaminophen, but there are important differences in glucuronate and sulfate conjugates.
A natural complex sugar of the glycosaminoglycan family, hyaluronan is a high molecular weight polysaccharide composed of repeating disaccharide units of sodium glucuronate and N-acetylglucosamine.
Enzymatic treatment of human plasma samples found that EGCG is minimally conjugated to glucuronate or sulfate, however, EGC and EC were found to be extensively glucuronidated or sulfated (Chow et al.
5%) is conjugated with glucuronic acid to form a nonvolatile, water-soluble metabolite called ethyl glucuronate.
Aldosterone, cholesterol, cortisone, cortisol, danazol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, estradiol, estradiol glucuronate, estriol, estrone, progesterone, corticosterone, testosterone, norethindrone, pregnenolone sulfate, 11-deoxycortisol, 17[alpha]-hydroxypregnenolone, and 17[alpha]-hydroxyprogesterone at concentrations of [10.
In contranst to P-gp, MRP-1 is primarily an active transporter of GSH, oxidized GSH, glucuronate and sulfate conjugated organic anions (Borst et al.
both conjugated and unconjugated) metanephrine and normetanephrine, sulfate and glucuronate conjugates were firstly acid hydrolyzed such that all metanephrines were in their free form before acylation.