glycotoxicity

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glycotoxicity

(glī'kō-tok-sis'i-tē),
Pathologic changes in organs caused by elevated levels of glucose (for example, diabetes).
Synonym(s): glucotoxicity
References in periodicals archive ?
T2DM is associated with insulin secretion disorder of [beta] cells and insulin resistance, which is defined as the deterioration of normal biological response to exogenous and endogenous insulin, and many resultants can be regarded, such as genetic factors, cellular receptor mechanism, low birth weight, obesity, lifestyle, glucotoxicity, lipotoxicity, islet amyloid, adiposyte products, and inflammation (6).
Glucose-induced [beta] cell production of IL-1 b contributes to glucotoxicity in human pancreatic islets.
Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications.
2 In type 2 diabetes mellitus, deranged glycaemic control induces glucotoxicity and lypotoxicity exposing the cellular environment to free fatty acid surge which drives beta cell apoptosis and insulin resistance.
Thus, metabolically utilizing ("burning") oxygen and sugar for efficient production of energy comes at a potentially high metabolic price: free radical toxicity and protein glycation or glucotoxicity.
The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity," PLoS ONE, vol.
Reasons for the increasing of lipid profile may be associated with the mechanism of glucotoxicity improvement or different percentage of usage of lipid lowering therapy between groups, or other reasons we still no know.
2]S led to the identification of protective effects from ischemic insults in the heart and kidney and from high-fat diet-induced glucotoxicity in pancreatic O cells.
The data indicated that paeoniflorin could block glucotoxicity in biological cells or tissues.
In our study, decreasing total proinsulin + insulin level indicated insulin secretion defect and support the glucotoxicity and lipotoxicity phenomenon in type 2 DM (Dimitrova and Georgiev 2007).