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glucosylceramidase

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glucosylceramidase /glu·co·syl·cer·am·i·dase/ (gloo″ko-sil-ser-am´ĭ-dās) an enzyme that catalyzes the hydrolytic cleavage of glucose from glucocerebrosides to form ceramides in the lysosomal degradation of sphingolipids. Deficiency of enzyme activity, an autosomal recessive trait, results in Gaucher disease.
glucosylceramidase
see β-glucocerebrosidase.


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Investigation of the topic of Gaucher's disease at the Medical Faculty of the University of Amsterdam has led to the discovery of a membrane-bound non-lysosomal glucosylceramidase [16] (Fig.
 
 
 
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