glucose-dependent insulinotropic polypeptide


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glucose-dependent insulinotropic polypeptide

an insulinotropic substance originating in the gastrointestinal tract and released into the circulation following ingestion of a meal containing glucose.

gluc·ose-de·pen·dent in·su·lin·o·tro·pic pol·y·pep·tide

(glū'kōs-dĕ-pen'dĕnt in'sŭ-lin-ō-trō'pik pol'ē-pep'tīd)
An insulinotropic substance originating in the gastrointestinal tract and released into the circulation following ingestion of a meal containing glucose.

gluc·ose-de·pen·dent in·su·lin·o·tro·pic pol·y·pep·tide

(glū'kōs-dĕ-pen'dĕnt in'sŭ-lin-ō-trō'pik pol'ē-pep'tīd)
Insulinotropic substance originating in gastrointestinal tract and released into the circulation following ingestion of food containing glucose.
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References in periodicals archive ?
A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans.
Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats.
Major glucose regulating incretin hormones are glucagon like peptide-1 (GLP-I) and glucose-dependent insulinotropic polypeptide (GIP) produced from the L-cells and K-cells of the intestinal mucosa, respectively.
And changes in a gut hormone called glucose-dependent insulinotropic polypeptide also seem to contribute to diabetes reversal.
Alternatively, iAs exposure could interfere with the production or signaling of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) that, respectively, induce insulin secretion from the pancreatic [beta] cells and suppress glucagon release from the a cells during meals.
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.
Hydrolysis of whey protein is known to influence the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), but the study did not determine whether the increase in insulin stimulation was linked to an increase in secretion of these incretin hormones.
Also currently on the market is sitagliptin, the first DPP-4 inhibitor, which prolongs and enhances the action of endogenous GLP-1 and glucose-dependent insulinotropic polypeptide.
First isolated and characterized by Brown (14) in 1971, gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid peptide secreted by the enteroendocrine K cells located in the duodenum and proximal jejunum.
appears to inhibit the enzyme dipeptidyl peptidase IV (DPP-IV), which in-activates the incretin gut hormones glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
These inhibitors prevent DPP-4 from breaking down the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thereby increasing the levels of these hormones in the blood and potentially in the digestive tract as well.
Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects.

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