glucose-6-phosphate dehydrogenase


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Related to glucose-6-phosphate dehydrogenase: pentose phosphate pathway, glucose-6-phosphate dehydrogenase test

dehydrogenase

 [de-hi´dro-jen-ās″]
an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor.
glucose-6-phosphate dehydrogenase an enzyme necessary for the oxidation of glucose-6-phosphate, an intermediate in carbohydrate metabolism. Hereditary deficiency of this enzyme in the erythrocytes is associated with a tendency toward hemolysis upon ingestion of certain antimalarial agents and sulfonamide drugs and fava beans (see favism.
lactate dehydrogenase (LDH) an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver, and myocardium. It appears in elevated concentrations when these tissues are injured.

glu·cose-6-phos·phate de·hy·dro·gen·ase

(glū'kōs fos'fāt dē'hī-droj'en-ās),
An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-δ-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.

glucose-6-phosphate dehydrogenase

/glu·cose-6-phos·phate de·hy·dro·gen·ase/ (G6PD) (-fos´fāt de-hi´dro-jen-ās) an enzyme of the pentose phosphate pathway which, with NADP+ as coenzyme, catalyzes the oxidation of glucose 6-phosphate to a lactone. Deficiency of the enzyme causes severe hemolytic anemia.

glucose-6-phosphate dehydrogenase (G-6-PD)

an important enzyme in the PENTOSE PHOSPHATE PATHWAY for carbohydrate metabolism, catalysing the oxidation of glucose 6-phosphate in the presence of NADP coenzyme, giving 6-phosphogluconolactone and NADPH. G-6-PD of blood erythrocytes is of particular interest because a decrease in its activity can lead to the condition called FAVISM.

dehydrogenase

an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor, such as NAD+ or FAD+.

alcohol dehydrogenase
dimeric enzyme protein of the liver catalyzing the NAD+-linked dehydrogenation of ethanol to acetaldehyde.
glucose-6-phosphate dehydrogenase
see glucose-6-phosphate dehydrogenase.
glutamate dehydrogenase (GD), glutamic dehydrogenase
an enzyme that catalyzes the reversible reaction of glutamic acid into 2-oxoglutaric acid and ammonia. High concentrations occur in the liver of sheep, cattle, horses and dogs. Serum levels are useful in detecting hepatocellular damage in ruminants.
l-iditol dehydrogenase (ID)
a liver specific enzyme; serum determinations have been used in the horse to detect hepatocellular damage. Called also sorbitol dehydrogenase, SDH.
isocitrate dehydrogenase (ICD)
an enzyme found in high concentrations in many tissues. Two major forms of the enzyme, an NAD+-dependent ICD associated with the mitochondrial TCA cycle and a NADP+-dependent ICD associated with fat synthesis in adipose tissue and lactating mammary gland of ruminants or with steroidogenesis in endocrine tissues. Serum levels have been used to detect hepatocellular damage, but it is not highly specific.
lactate dehydrogenase (LDH), lactic acid dehydrogenase
an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver and myocardium. It appears in elevated concentrations when these tissues are injured. See also mouse lactic dehydrogenase elevating virus.
lactate dehydrogenase agent
polyol dehydrogenase
sorbitol dehydrogenase (SDH)
References in periodicals archive ?
Favism in the African type of glucose-6-phosphate dehydrogenase deficiency (A-) Br M J 1990; 300: 236.
Predictive role of laboratory and clinical treatment response parameters and glucose-6-phosphate dehydrogenase status in the therapy of falciparum malaria.
Glucose-6-phosphate dehydrogenase activity also showed a pattern of up and down with an increase of dietary CBH (Table 4).
A colorimetric method for assay of erythrocyte glucose-6-phosphate dehydrogenase.
Pathophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency.
Key Words: methaemoglobinaemia, aniline, methylene blue, glucose-6-phosphate dehydrogenase
Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.
2]), 8 mM Aminopyrine (3780 [micro]l of 10mM aminopyrine) and 10 units of glucose-6-phosphate dehydrogenase was mixed with 9129 [micro]l of buffer 1 in a 125 ml Erlenmeyer flask.
Primaquine may cause nausea, abdominal pain and oxidant haemolysis with methemoglobinemia,anemia, hemoglobinurea, and is contraindicated in patients with different variants of glucose-6-phosphate dehydrogenase deficiency (1).
When dapsone therapy is anticipated, the patient's glucose-6-phosphate dehydrogenase (G6PD) level should be measured because patients who have a deficiency of this enzyme are more prone to develop hemolysis while taking dapsone.
MOVIPREP should be used with caution in patients at risk of or with fluid and electrolyte abnormalities, hyponatremia, arrhythmias, seizures, in patients with impaired renal function or patients taking concomitant medications that affect renal function, patients with known or suspected inflammatory bowel disease, patients with suspected GI obstruction or perforation, patients at risk for aspiration, and patients with glucose-6-phosphate dehydrogenase deficiency.

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