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Related to glucose-6-phosphate: glucose-6-phosphate dehydrogenase, Glucose-6-phosphate dehydrogenase deficiency, glucose-6-phosphate dehydrogenase test


(glū'kōs fos'fāt)
An ester of glucose with phosphoric acid; made in the course of glucose metabolism by mammalian and other cells; a normal constituent of resting muscle.

glucose, d-glucose

a simple sugar, a monosaccharide in certain foodstuffs, especially fruit, and in normal blood; the major source of energy for many living organisms. See also dextrose.
Glucose, whose molecular formula is C6H12O6, is the end product of carbohydrate digestion; other monosaccharides (fructose and galactose) are largely converted into glucose. Glucose is the only monosaccharide present in significant amounts in the body fluids. The oxidation of glucose produces energy for the body cells; the rate of metabolism is controlled by a number of hormones the most important of which are insulin and glucagon. Glucose that is not needed for energy is stored in the form of glycogen as a source of potential energy, readily available when needed. Most of the glycogen is stored in the liver and muscle cells. When these and other body cells are saturated with glycogen, the excess glucose is converted into fat and stored as adipose tissue. See also hypoglycemia, hyperglycemia.

radioactive glucose used experimentally.
liquid glucose
a thick syrupy, sweet liquid, consisting chiefly of dextrose, with dextrins, maltose and water, obtained by incomplete hydrolysis of starch; used as a flavoring agent, as a food, and in the treatment of dehydration.
an intermediate in carbohydrate metabolism.
a liver (and kidney) enzyme that irreversibly cleaves glucose-6-phosphate to free glucose and phosphate; important in glucose homeostasis.
an intermediate in carbohydrate metabolism.
glucose-6-phosphate dehydrogenase (G6PD)
a regulatory enzyme in the metabolism of glucose-6-phosphate. A deficiency of the enzyme in the erythrocyte results in a hemolytic anemia; an inherited abnormality in humans, rats and mice and acquired in animals in phenothiazine toxicity and ingestion of kale.
glucose phosphate isomerase
converts glucose-6-phosphate to fructose-6-phosphate and the reverse reaction.
glucose suppression test
suppression of blood levels of growth hormone by the intravenous administration of glucose is used to diagnose acromegaly.
glucose tolerance factor (GTF)
a naturally occurring substance containing chromium which potentiates the effects of insulin.
glucose tolerance test
a test of the body's ability to utilize carbohydrates. It is often used to detect abnormalities of carbohydrate metabolism such as occur in diabetes mellitus, hypoglycemia, and liver and adrenocortical dysfunction. If administered orally, it may also be used to assess the absorptive capacity of the small intestine.
References in periodicals archive ?
Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts.
Malate dehydrogenase, pyruvate kinase, and glucose-6-phosphate dehydrogenase activities were not affected significantly by dietary CBH levels.
Special modifications of the fluorescent screening method for glucose-6-phosphate dehydrogenase deficiency.
Favism in the African type of glucose-6-phosphate dehydrogenase deficiency (A-) Br M J 1990; 300: 236.
glucose-6 phosphate, and glucose-6-phosphate dehydrogenase grade 11 (5 g/L) were purchased from Boehringer Mannheim.
3] Nonstandard abbreviations: GALT, galactose-1-phosphate uridyltransferase; Gal-1-P, galactose-1-phosphate; G6PD, glucose-6-phosphate dehydrogenase; Fl, fluorescence intensity; and RBC, red blood cell.
The expression of uridine diphosphate glucuronosyltransferase gene is a major determinant of bilirubin level in heterozygous [beta]-thalassaemia and in glucose-6-phosphate dehydrogenase deficiency.
Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonate are missed during routine screening.
Marks provided the first direct evidence that a genetically determined enzyme defect in glucose-6-phosphate dehydrogenase (G6PD) predisposed to hemolytic anemia.
A total of 112 glucose-6-phosphate dehydrogenase (G6PD) variants involving a single amino acid change have been reported (7), with their clinical impact classified according to the WHO from I, for the more severe, to 1V for those that are functionally neutral (8).
Hemolytic neonatal jaundice, which is mainly attributable to glucose-6-phosphate dehydrogenase deficiency, is a major problem in Greece and in most Mediterranean countries (16,17).

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