glucose toxicity


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glucose toxicity

1. The decrease in insulin secretion and the increase in insulin resistance due to excessively high blood glucose levels.
2. Damage to arteries, the kidneys, nerves, the retina, and other tissues due to high blood glucose concentrations. Synonym: glucotoxicity
See also: toxicity
References in periodicals archive ?
Glucose toxicity in -cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection.
Rossetti L, Giaccari A, DeFronzo RA: Glucose toxicity.
EFFECT OF GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Specifically, we assessed: (1) deoxyglucose uptake in differentiated C2C12 muscle cells and 3T3-L1 adipocytes; (2) glucose-stimulated insulin secretion (GSIS) in [beta] TC-tet pancreatic [beta] cells; (3) [beta] cell proliferation in [beta] TC-tet cells; (4) lipid accumulation in differentiating 3T3-L1 cells; (5) protection against glucose toxicity in PC12 cells.
Not only does it bring down blood glucose, it may act synergistically with other agents to reduce glucose toxicity.
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