Chronic hyperglycemia also induces myriad of biological reactions causing glucose toxicity
, which in turn causes [beta]-cell apoptosis [99-101].
in -cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection.
Rossetti L, Giaccari A, DeFronzo RA: Glucose toxicity
EFFECT OF GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY
IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Low levels are not necessarily an indication of type 1, however, because patients with type 2 diabetes may have low levels of insulin and C-peptide because of glucose toxicity
and lipotoxicity at the time of diagnosis.
Specifically, we assessed: (1) deoxyglucose uptake in differentiated C2C12 muscle cells and 3T3-L1 adipocytes; (2) glucose-stimulated insulin secretion (GSIS) in [beta] TC-tet pancreatic [beta] cells; (3) [beta] cell proliferation in [beta] TC-tet cells; (4) lipid accumulation in differentiating 3T3-L1 cells; (5) protection against glucose toxicity
in PC12 cells.
The progression from impaired glucose tolerance to type 2 diabetes is related to decreasing [beta]-cell insulin secretion because insulin resistance does not appear to worsen substantially unless hyperglycemia with glucose toxicity
10) It has been shown that accelerated deterioration in [beta]-cell function may be influenced by glucose toxicity
and insulin resistance.
17) Residual postprandial hyperglycemia contributes to glucose toxicity
and limits efforts to reduce A1C levels from 7% to the normal range of 4% to 6%.