glucose toxicity


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glucose toxicity

1. The decrease in insulin secretion and the increase in insulin resistance due to excessively high blood glucose levels.
2. Damage to arteries, the kidneys, nerves, the retina, and other tissues due to high blood glucose concentrations. Synonym: glucotoxicity
See also: toxicity
References in periodicals archive ?
Chronic hyperglycemia also induces myriad of biological reactions causing glucose toxicity, which in turn causes [beta]-cell apoptosis [99-101].
Glucose toxicity in -cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection.
Rossetti L, Giaccari A, DeFronzo RA: Glucose toxicity.
EFFECT OF GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Low levels are not necessarily an indication of type 1, however, because patients with type 2 diabetes may have low levels of insulin and C-peptide because of glucose toxicity and lipotoxicity at the time of diagnosis.
Specifically, we assessed: (1) deoxyglucose uptake in differentiated C2C12 muscle cells and 3T3-L1 adipocytes; (2) glucose-stimulated insulin secretion (GSIS) in [beta] TC-tet pancreatic [beta] cells; (3) [beta] cell proliferation in [beta] TC-tet cells; (4) lipid accumulation in differentiating 3T3-L1 cells; (5) protection against glucose toxicity in PC12 cells.
The progression from impaired glucose tolerance to type 2 diabetes is related to decreasing [beta]-cell insulin secretion because insulin resistance does not appear to worsen substantially unless hyperglycemia with glucose toxicity supervenes (16).
10) It has been shown that accelerated deterioration in [beta]-cell function may be influenced by glucose toxicity and insulin resistance.
17) Residual postprandial hyperglycemia contributes to glucose toxicity and limits efforts to reduce A1C levels from 7% to the normal range of 4% to 6%.
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