2008) Early exercise advances the maturation of glucosaminoglycans
and collagen in the extracellular matrix of articular cartilage in the horse.
The mercury is later taken up by protein molecules (enzymes) within the brain, by glucosaminoglycans
(GAGs) in the extracellular matrix, receptors on cell walls, enzymes, structural molecules and GTP (the enzyme that creates tubulin), enzymes of the citric acid cycle within the mitochondria, and more.
It aids production of glucosaminoglycans
(GAGs) in synovial fluid, ensuring lubrication, shock absorption and elasticity.
Biochemical stimulation of the nociceptors due to extravasation of glucosaminoglycans
(chondroitin sulphates) and other biochemical irritants (substance P, glutamate and its receptor NMDAR1) has been suggested in more recent theories (Ackermann et al.
The matrix is the space between the cells - the area in the body that includes the blood vessels, lymphatic vessels, autonomic nerves, fibroblasts, collagen, elastin, glucosaminoglycans
, proteoglycans, cell membranes of neighboring cells, cells of the immune system, and nutrients.