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treated 252 patients with osteoarthritis of the knee with 1500 mg/day glucosamine sulfate for four weeks.
As assessed by WOMAC scores, symptoms worsened slightly in patients on placebo compared with the improvement observed after treatment with glucosamine sulfate.
In a meta-analysis that pooled the results of four studies, the 428 people who took at least 1,500 mg a day of glucosamine sulfate (Instaflex has 1,250 mg) experienced no more relief from their arthritis pain than the 432 people who took a (look-alike but inactive) placebo.
Comment: Most, but not all, studies have found that glucosamine sulfate is an effective treatment for osteoarthritis of the knee and for osteoarthritis affecting certain other areas of the body.
Researchers aimed to see if a combination of glucosamine sulfate (1500 mg/day) and the omega 3 polyunsaturated fatty acids EPA and DHA would be more effective than glucosamine sulfate alone.
According to True Botanica, the product offers a natural alternative to glucosamine sulfate, chondroitin, MSM, and other chemically derived joint health products.
3 Long term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled clinical trial JY.
In a randomized trial, 32 patients with knee osteoarthritis (OA) applied as needed the topical cream containing glucosamine sulfate 30 mg/g, chondroitin sulfate 50 mg/g, shark cartilage 140 mg/g, camphor, and peppermint oil.
Many people take glucosamine sulfate with chondroitan sulfate, even though glucosamine sulfate is much, much more absorbable.
In one of the first clinical trials performed in the United States, glucosamine sulfate failed to outperform a placebo for the treatment of osteoarthritis.
Glucosamine sulfate is not an anti-inflammatory, but instead provides your body the raw materials to help improve the integrity of the joint space.