glucokinase


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glucokinase

 [gloo″ko-ki´nās]
an enzyme that in the presence of ATP catalyzes glucose to glucose-6-phosphate.

glu·co·ki·nase

(glū'kō-kī'nās), [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and ATP to d-glucose 6-phosphate and ADP; the liver enzyme has a higher Km value for d-glucose than hexokinase and is not strongly inhibited by the product d-glucose 6-phosphate.

glucokinase

/glu·co·ki·nase/ (-ki´nās)
1. an enzyme of invertebrates and microorganisms that catalyzes the phosphorylation of glucose to glucose 6-phosphate.
2. the liver isozyme of hexokinase.

GCK

A gene on chromosome 7p15.3-p15.1 that encodes a glucokinase (hexokinase) that phosphorylates glucose yielding glucose-6-phosphate, the first usual step in glucose metabolism.

Molecular biology
GCK mutations are linked to type-2 diabetes, maturity-onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycaemia of infancy (PHHI).

glu·co·ki·nase

(glū'kō-kī'nās)
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate; the liver enzyme has a higher Km value for d-glucose than does hexokinase.

glu·co·ki·nase

(glū'kō-kī'nās) [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate.

glucokinase,

n a hexokinase or phosphotransferase that catalyzes the conversion of glucose to glucose-6-phosphate by ATP.

glucokinase

an enzyme that in the presence of ATP catalyzes glucose to glucose-6-phosphate.
References in periodicals archive ?
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
2) Besides its role as a carboxylase prosthetic group, biotin exhibits principal effects on glucokinase expression in the liver and pancreas, glucokinase is a key enzyme in the glycolysis pathway which increases glucose catabolism and regulates blood glucose metabolism and plasma lipids concentrations.
88) Fructose which is present in significant proportions in most honeys has been shown to enhance glucokinase and glycogen synthase activities and inhibit phosphorylase activity in the liver.
Glucokinase is an enzyme that regulates the uptake of glucose from the blood.
had entered into an agreement with Amgen in December 2009 for the worldwide development of the small-molecule glucokinase activator (GKA) programme, including AMG 151.
Inhibition of glucokinase and hexokinase from pancreatic B-cells and liver by alloxan, alloxantin, dialuric acid, and t-butylhydroperoxide.
Studies have shown that diabetes might be arised from chromosome 6q24 abnormalities and mutations in the genes (KCNJ11 and ABCC8) coding glycolytic enzymes, glucokinase and two protein subunits (Kir6.
29 December 2011 - Chinese Hua Medicine said last week it had licensed Swiss Roche's (VTX:ROG) Glucokinase Activator (GKA) programme.
Growing evidence on the effects of mutations in the glucokinase (GCK) gene, which appear to account for approximately 5% of gestational diabetes cases in white mothers, may similarly drive screening efforts in the future, he said.
Despite alloxaninduced diabetes is a multifactor promoted diabetes model which still used to examine the antidiabetic effects of different compounds is being inconsistent or differ with the natural pathogenesis of human diabetes, further research on the causes of decreased liver- specific glucokinase activity is required which will help us to unravel the pathogenesis of diabetes and its complications.
The conversion of glucose to glucose-6-phosphatase by glucokinase is the key step governing substrate input into the glycolytic pathway in [beta]-cells.
In addition, a SNP in the gene glucokinase (hexokinase 4) regulator (GCKR), which encodes glucokinase regulatory protein, was found to have a highly significant association with triglyceride concentrations (67).