glucokinase


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glucokinase

 [gloo″ko-ki´nās]
an enzyme that in the presence of ATP catalyzes glucose to glucose-6-phosphate.

glu·co·ki·nase

(glū'kō-kī'nās), [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and ATP to d-glucose 6-phosphate and ADP; the liver enzyme has a higher Km value for d-glucose than hexokinase and is not strongly inhibited by the product d-glucose 6-phosphate.

glucokinase

/glu·co·ki·nase/ (-ki´nās)
1. an enzyme of invertebrates and microorganisms that catalyzes the phosphorylation of glucose to glucose 6-phosphate.
2. the liver isozyme of hexokinase.

GCK

A gene on chromosome 7p15.3-p15.1 that encodes a glucokinase (hexokinase) that phosphorylates glucose yielding glucose-6-phosphate, the first usual step in glucose metabolism.

Molecular biology
GCK mutations are linked to type-2 diabetes, maturity-onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycaemia of infancy (PHHI).

glu·co·ki·nase

(glū'kō-kī'nās)
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate; the liver enzyme has a higher Km value for d-glucose than does hexokinase.

glu·co·ki·nase

(glū'kō-kī'nās) [MIM*138079]
Phosphotransferase that catalyzes the conversion of d-glucose and adenosine triphosphate d-glucose 6-phosphate and adenosine diphosphate.

glucokinase,

n a hexokinase or phosphotransferase that catalyzes the conversion of glucose to glucose-6-phosphate by ATP.

glucokinase

an enzyme that in the presence of ATP catalyzes glucose to glucose-6-phosphate.
References in periodicals archive ?
5 mmol/L at 2 hours after a 75-g load, that's much more likely to be glucokinase, whereas most HNF1[alpha] patients have an increment of more than 5 mmol/L," he told this newspaper.
Bell's team asserts that the defect causes MODY patients to produce insufficient amounts of glucokinase, which they believe is required for pancreatic cells to detect sugar concentrations in the blood.
Glucokinase is the enzyme that acts as a glucose sensor in the pancreas and liver.
Further, the molecular interaction study of the ligands 1, 2 and glibenclamide with various diabetes mellitus related protein targets like glucokinase (PDB ID: 1V4S), fructose-1,6-bisphosphatase 1 (PDB ID: 2JJK) 11-[beta]-hydroxysteroid dehydrogenase (PDB ID: 2BEL) and modeled protein sulfonylurea receptor 1 (SUR1) showed that ligand 1 and 2 possess binding affinity with all protein targets except for 2BEL target protein for which ligand 1 has no interaction.
glucokinase mutations producing maturity-onset diabetes of the young 2).
Activated by insulin, SREBP-1c regulates lipoprotein lipase, fatty acid synthase, peroxisome proliferator-activated receptor (PPARy), and glucokinase, thereby playing an important role in cholesterol, triglyceride, and glucose metabolism, and SREBP-1c adipocyte expression has been linked to lipoatrophy in HIV-infected patients Moreover, indinavir decreases SRBP-1c expression and nuclear localization while promoting apoptosis of adipocytes].
We observed that a common genetic variant known as Patatin-like phospholipase domain containing protein-3 (PNPLA3) working with a regulatory protein called glucokinase (GCKR), was associated with increased triglycerides, very low-density lipoproteins levels, and fatty liver," said Santoro.
We obtained antibodies for Nrf2 (sc-13032; 1:500), glucokinase (GCK; sc-7908; 1:1000), glucose transporter 2 (Glut2, sc-9117; 1:1000), potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11, also termed KIR6.
Agent Comment Metformin Increased insulin sensitivity, reduction of glucogenesis, inhibition of excessive glucose absorption, enhanced glycolysis by increasing gene expression that encodes for glucokinase and liver-specific pyruvate kinase.
Biotin enhances insulin sensitivity and increases the activity of glucokinase, the enzyme responsible for the first step in the utilization of glucose by the liver.
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels.
Select Partnered Programs and New Partnering Agreements AMG 151 (ARRY-403) (Amgen) - Glucokinase Activator for Type 2 diabetes: In October 2011, Amgen initiated a Phase 2a, 28-day trial of AMG 151 in combination with metformin in approximately 224 patients with Type 2 diabetes.