glucocorticoid resistance


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glucocorticoid resistance

defective response of target tissues to glucocorticoids; a common acquired state frequently associated with allergic or autoimmune conditions (for example, asthma or rheumatoid arthritis) or severe inflammatory states (for example, respiratory distress syndrome or septic shock); also occurs as a rare genetic syndrome resulting from malfunction of glucocorticoid receptor.

glucocorticoid resistance

1. A rare genetically inherited insensitivity of peripheral tissues to the effects of steroid hormones produced by the adrenal cortex. Affected patients produce excessive compensatory quantities of ACTH and may be affected by hyperandrogenism or mineralocorticoid excess.
2. Insensitivity to treatment with glucocorticoid drugs, e.g., prednisone for asthma or Crohn disease.
See also: resistance
References in periodicals archive ?
Such glucocorticoid resistance is a noted feature in many patients with major depression.
There is indication that splice events may impact hormonal or glucocorticoid resistance in several cancer treatments," stated Bruno Tocque, CEO ExonHit Therapeutics, "therefore, we are very pleased to be able to offer this array focused on these molecules to bring a better level of resolution to gene expression.

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