glomerulosclerosis index

glomerulosclerosis index

An index which semi-quantifies the degree of glomerulosclerosis in a renal biopsy based on the number of glomeruli with sclerosis and the percentage of sclerosis in each of the assessed glomeruli.

Method
PAS-stained tissue is examined at 400X; a score of 0 is assigned to normal glomeruli, 1 for up to 25% involvement, 2 for up to 50% involvement, 3 for up to 75%, and 4 for greater than 75% sclerosis. The GSI is calculated as GSI = [(1 x N1) + (2 x N2) + (3 x N3) + (4 x N4)]/(N0 + N1 + N2 + N3 + N4), where Nx is the number of glomeruli with each given score for a given section.
References in periodicals archive ?
After 12 weeks, in the pedicled greater omentum flaps packing ESC-loaded GMs on 5/6 nephrectomized rats group, the plasma urea nitrogen levels were 26% lower than in the right nephrectomy group, glomerulosclerosis index was 62% lower and tubular injury index was 40% lower than in the 5/6 nephrectomized rats group without GMs.
The overall glomerulosclerosis index and tubular injury score (mean [+ or -] standard error of the mean [SEM]) were computed from the individual means of all of the rats in the group.
18] The glomerulosclerosis index and urine albumin excretion in rats with subtotal nephrectomy decreased by the endogenous VDR ligand, calcitriol.
This simple fact could explain the association between the decreased sympathetic tonus and the reduction of the glomerulosclerosis index found in this present study.
Forbes et al [49] demonstrated that the administration of ALT 711, an advanced glycosylation end product inhibitor, readily reduced the glomerulosclerosis index, the tubulointerstitial area, and albuminuria in diabetic rats.