Incidences of nephropathy and, in the adrenal cortex, hypertrophy of the zona glomerulosa
and atrophy of the zona reticularis were significantly increased at 2,000x compared with controls (see Supplemental Material, Table S9), with severity increasing with dose for the adrenal observations.
In this study, the zona glomerulosa
appeared intact in the two rats found to have alteration of adrenal gland.
At the microscopic level, we saw a typical cell pattern of zona glomerulosa
, with scattered hematopoietic elements.
This finding is most likely due to the higher progesterone concentrations in premenopausal women, given that in vitro studies have shown that progesterone increases aldosterone production in zona glomerulosa
The dough isn't completely cooked, so there are three layers--the different zones, with the zona glomerulosa
being the outermost.
Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3[beta]-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa
Conn's syndrome (primary aldosteronism)-excess production of mineralocorticoid aldosterone due to hyperplasia or neoplasm of zona glomerulosa
of the adrenal cortex-is also a rare disorder.
PTH stimulates aldosterone secretion from adrenal glomerulosa
cells in a dose-dependent manner, both alone and in combination with angiotensin II.
The cortex is of mesodermal origin and is composed of 3 zones: zona reticularis, zona fasciculata, and zona glomerulosa
Also immunolabeled in the wolf were a few myocardial cells and several small clusters of cells in the zona glomerulosa
of the adrenal gland.
I wrote some papers showing aldosterone coming from the outer cortex, the zona glomerulosa
, and cortisone coming from the midzone.
4] Of the 3 cortical layers, zona fasciculata and glomerulosa