0])) was plotted against the logarithm of the MW of globular proteins
and purified cardiac troponin standards.
Several implications of the epitope analysis we have performed argue against hcTnI being globular, at least in the uncomplexed form that was used for immunization: (a) all 16 anti-hcTnI mAbs recognized a continuous epitope markedly; this contrasts with the observation that most mAbs to globular proteins
show a conformation-dependent recognition  and, therefore, do not react with short peptides; (b) several helices of hcTnI are antigenic, which means that they are probably exposed to the solvent and not packed together as in globular proteins
; and (c) we observed that regions connecting the predicted helices of hcTnI are not antigenic; this is in sharp contrast with the fact that turn regions in globular proteins
are generally antigenic.
In natural states, proteins generally exist in two form fibrous proteins and globular proteins
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The molecular backbones of globular proteins
have an intricates structure.
Force to Unbind Ligand-Receptor Complexes and the Internal Rigidity of Globular Proteins
Probed by Single-Molecule Force Spectroscopy
s] than globular proteins
with a comparable relative molecular mass ([M.