glitazones

glitazones

Thiazolidinedione derivative drugs used to treat type II (non-insulin-dependent) diabetes mellitus. Glitazones act by altering fatty acid metabolism by way of peroxisome proliferator-activated receptors which, in effect, increase cell sensitivity to insulin.

thiazolidinediones

; TZD; glitazones oral agents reducing peripheral insulin resistance; used as part of glycaemic control in patients with diabetes mellitus; e.g. pioglitazone, rosiglitazone; may be used in conjunction with metformin (but tend to hypoglycaemia if used with sulphonylurea); there is a reported increased incidence of fractures of small bones in postmenopausal women using TZD
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agreed, noting the glitazones, or thiazolidinediones, aren't known to cause myocardial dysfunction; in fact, animal studies suggest just the opposite--that these drugs improve left ventricular dysfunction in the post-MI setting.
agreed with this assessment, noting the glitazones, or thiazolidinediones, aren't known to cause myocardial dysfunction; in fact, animal studies suggest just the opposite--that these drugs improve left ventricular dysfunction in the post-MI setting.
The draft USP guidelines, which were released in August, have come under fire from physicians and patient advocates, who say that organization of drug classes and categories in the draft would not require drug plans to cover critical medications such as statins, glitazones, and selective serotonin reuptake inhibitors.
Also included as part of the invention are products combining torsemide with antidiabetics, such as glitazones.
The draft USP guidelines, which were released last August, came under fire from physicians and patient advocates, who complained that the organization of classes and categories in the draft would not require participating drug plans to cover several critical medications including statins, glitazones, and selective serotonin reuptake inhibitors.
Pharmacopeia do not include coverage of statins, glitazones, selective serotonin reuptake inhibitors (SSRIs), and other critical drugs, said Joseph Cranston, Ph.
Though Metformin will continue to be a key drug in treatment, oral drug classes such as Glitazones and Sulphonylurea (SFU) will be eventually replaced by more advanced therapies such as GLP-1s and DPP-IVs.
Drug therapy presents a conundrum: The two available classes of insulin sensitizing agents, metformin and the glitazones, are contraindicated in patients with liver disease.
PPAR-[gamma] is found mainly in fat tissue; the glitazones used for their insulin-sensitizing effects in treating type 2 diabetes have PPAR-[gamma]-agonist effects.
Unlike the glitazones, TRIOLEX does not cause body weight gain when administered to mice or rats.
BOSTON -- Two small studies of glitazones presented at the annual meeting of the American Society for the Study of Liver Diseases indicate that two of these insulin sensitizing drugs approved for the treatment of diabetes may be useful in the treatment of nonalcoholic steatohepatitis.