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Related to glitazone: metformin, Sitagliptin, Sulfonylureas


Shorthand term for a class of oral hypoglycemics that have glitazone as a component in their names.
Synonym(s): thiazolidinedione
References in periodicals archive ?
Coefficients of variation for A1c-lowering treatments ranged from 23 percent (adding glitazone to sulfonylurea) to 76 percent (adding mefformin to sulfonylurea).
DME risk remained 60 percent higher for glitazone users even after further adjustment for other factors.
A hallmark of glitazone (thiazolidinedione)-like activity is enhanced adipogenesis mediated through PPAR[gamma] receptor activation.
Here's what triple-drug therapy with metformin, a sulfonylurea, and a glitazone accomplishes, as demonstrated in a 200-patient trial in which patients on metformin and a sulfonylurea were randomized to troglitazone or placebo.
Fast acting Insulins, Long acting Insulins, Intermediate and Fast acting Insulins, Intermediate acting Insulins, Biguanides, Glitazone and Biguanide combinations, Biguanide and Sulphonylurea combinations, Glinides, Sulphonylureas, Glitazones, DPP-IV Inhibitors, Glp-1 Agonists, Alpha-Glucosidase Inhibitors, DPP-IV Inhibitor and Biguanide combinations, Glitazone and Sulphonylurea combinations, SGLT Inhibitors, SGLT Inhibitor and Biguanide combinations, PTP1B Inhibitors and all other Oral Antidiabetic classes.
It has been demonstrated that thiazoladinediones and glitazone decrease fasting blood glucose, cholesterol and triglycerides, and this may result in their potential ability to reduce macrovascular complications (Freie, 1999).
In vitro studies have suggested that drugs in the glitazone class stimulate production of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) protein, which plays a key role in adipocyte differentiation, and clinical trials have linked the drugs to increased subcutaneous fat in people with diabetes.
Nissen if the findings have changed his opinion regarding the glitazone class of drugs.
The glitazone class of drugs is well-established in treating Type II diabetes.
A new indication for glitazone therapy may prove to be NAFLD.
These top-line results are consistent with previously announced positive findings from a 12-week, Phase 2b study in which dutogliptin met all primary and secondary endpoints, including statistically significant reductions in HbA1c when administered once daily in combination with metformin, a glitazone, or metformin and a glitazone for the treatment of Type 2 diabetes.
The company also invented glitazone, the first class of antidiabetic medication to also have cardiovascular prevention effects.