may be the aftermath of such an autoimmune attack, says Siegel.
is a proliferation of astrocytes in the CNS in response to injury which results in scar formation.
HuVV mice were examined for evidence of astrocytic gliosis
In addition to evaluating regional neuronal loss and gliosis
, microvascular lesions, vascular brain injury, and hippocampal sclerosis, the dementia brain should always be investigated for AD and LBD pathology, regardless of the specific clinical diagnosis.
Histologic examination of the brain revealed microspongiosis, edema, gliosis
, and neuronal chromatolysis of surrounding periventricular tissue.
Axial FLAIR of the brain at 6-month follow-up (E) reveals almost complete resolution of the right basal ganglia lesion with some residual gliosis
primarily involving the caudate head.
2] Diffuse cerebral cortical atrophy may be symmetric or asymmetric, resulting from neuronal death and gliosis
, induced by the accumulation of GAGs.
Continuance of chorea despite normalization of blood glucose in some patients and the fact that abnormal movements are generally observed on the one side of the body are contradictory to a metabolic pathology, while the fact that chorea may be observed bilaterally and observation of only neuron loss, gliosis
and reactive astrocytosis, but not infarction or hemorrhagia are contradictory to vascular pathology (9,10).
chronic stage: gliosis
of the optic nerve head and eventually optic atrophy with nerve fibre damage and permanent visual field defect.
It is characterised by an autoimmune process involving autoreactive B- and T-cells that results in demyelination, axonal loss and resultant gliosis
The changes in the optic nerve head demonstrate that reactive gliosis
and microglial activation have occurred; however, these differences do not account for the differential effects of glaucoma in the D2 mouse relative to the B6 mouse.
The brain tissue of infected individuals will often show a reactive gliosis
in the absence of an inflammatory response, and protease-resistant PrP deposits are often easily detected.