glioblastoma multiforme


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glioblastoma

 [gli″o-blas-to´mah]
any malignant astrocytoma.
glioblastoma multifor´me astrocytoma grade III or IV; a rapidly growing tumor, usually of the cerebral hemispheres, composed of spongioblasts, astroblasts, and astrocytes.

gli·o·blas·to·ma mul·ti·forme

(glī'ō-blas-tō'mă mŭl'ti-fōrm),
A glioma consisting chiefly of undifferentiated anaplastic cells of astrocytic origin that show marked nuclear pleomorphism, necrosis, and vascular endothelial proliferation; frequently, tumor cells are arranged radially about an irregular focus of necrosis; these neoplasms grow rapidly, invade extensively, and occur most frequently in the cerebrum of adults.
[G. glia, glue, + blastos, germ, + -oma, tumor]

glioblastoma multiforme

[glī′ōblastō′mə mul′tifôr′mē]
Etymology: Gk, glia, glue, blastos, germ, oma, tumor; L, multus, many, forma, form
a malignant, invasive, rapidly growing pulpy or cystic tumor of the cerebrum or the spinal cord. The lesion spreads with pseudopod-like projections. It is composed of a mixture of monocytes, pyriform cells, immature and mature astrocytes, and neural ectodermal cells with fibrous or protoplasmic processes. Also called anaplastic astrocytoma, glioma multiforme.
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Glioblastoma multiforme

gli·o·blas·to·ma mul·ti·for·me

(glī'ō-blas-tō'mă mŭl'ti-fōr'mē)
A glioma consisting chiefly of undifferentiated anaplastic cells of glial origin that show marked nuclear pleomorphism, necrosis, and vascular endothelial proliferation; frequently, tumor cells are arranged radially about an irregular focus of necrosis; these neoplasms grow rapidly, invade extensively, and occur most frequently in the cerebrum of adults.
Synonym(s): grade IV astrocytoma.
[G. glia, glue, + blastos, germ, + -oma, tumor]

glioblastoma

an undifferentiated malignant astrocytoma.

glioblastoma multiforme
a rapidly growing tumor, usually of the cerebral hemispheres, often supratentorial.
References in periodicals archive ?
Food and Drug Administration (FDA) and the European Medicines Agency (EMA) earlier this year C to a randomized Phase 2 clinical trial in patients with glioblastoma multiforme.
This presents an opportunity to the drug makers to develop a therapy to treat glioblastoma multiforme with better efficacy and safety parameters.
In glioblastoma multiforme patients with high-grade cytomegalovirus infec-tion, median 2-year survival was 17.
Spinal leptomeningeal metastasis from cerebral glioblastoma multiforme presenting with radicular pain.
Scale to predict survival after surgery for recurrent glioblastoma multiforme.
Glioblastoma multiforme is the most deadly of all intracranial tumors.
The European Organization for Research and Treatment of Cancer (EORTC) 26981 protocol, which involved 85 centers in 14 countries, randomized 573 patients with newly diagnosed glioblastoma multiforme to daily focal radiation alone (30 X 200 cGy) or the same radiation protocol plus oral temozolomide, 75 mg/[m.
They also lowered VEGF levels in samples with glioblastoma multiforme, the most lethal type of brain tumour.
The following tumors were evaluated by these techniques: meningioma, astrocytoma, glioblastoma multiforme, neuroblastoma, ganglioneuroblastoma, neurofibromatosis, paranganglioma, schwannoma, and phaeochromocytoma.
DTI-015 is currently in human clinical trials in the United States for the treatment of glioblastoma multiforme (GBM), the most common and deadly form of brain cancer.
Glioblastoma multiforme accounts for about one-quarter of all primary CNS cancers in US adults.