glioblastoma


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

glioblastoma

 [gli″o-blas-to´mah]
any malignant astrocytoma.
glioblastoma multifor´me astrocytoma grade III or IV; a rapidly growing tumor, usually of the cerebral hemispheres, composed of spongioblasts, astroblasts, and astrocytes.

glioblastoma

/glio·blas·to·ma/ (gli″o-blas-to´mah) any malignant astrocytoma.
glioblastoma multifor´me  the most malignant type of astrocytoma, composed of spongioblasts, astroblasts, and astrocytes; it usually occurs in the brain but may occur in the brain stem or spinal cord.

glioblastoma

(glē′ō-blă-stō′mə, glī′-)
n. pl. glioblasto·mas or glioblasto·mata (-mə-tə)
A malignant tumor of the central nervous system, usually occurring in the cerebrum of adults.

glioblastoma

glioblastoma

Astrocytoma, grade III-IV, glioblastoma multiforme, malignant astrocytoma Neurosurgery A highly aggressive 1º brain tumor–BT arising in glia, comprising 30% of the 5000 new BTs/yr, US At risk occupations Anatomists, pathologists, dentists, ophthalmologists Treatment Poor response to surgery, chemotherapy, RT. See Gliadel® wafer.

glioblastoma

an undifferentiated malignant astrocytoma.

glioblastoma multiforme
a rapidly growing tumor, usually of the cerebral hemispheres, often supratentorial.
References in periodicals archive ?
A review of the Glioblastoma Multiforme (GBM) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Glioblastomas "reoccur because every cell that is left behind has the ability to start all over again," Verma said.
And that explains why Gahbauer's clinical trials will focus on 20 or 25 patients with glioblastoma multiforme; this brain tumor, which he notes currently accounts for about 2 percent of all cancer deaths in the United States, usually brings death within six months of diagnosis.
Avastin is currently approved in the United States for the treatment of adults with glioblastoma who have progressive disease following prior therapy.
ImmunoCellular has concluded a phase 2 trial of its lead product candidate, ICT-107, a dendritic cell-based immunotherapy targeting multiple tumor-associated antigens on glioblastoma stem cells.
Interim Analysis of EF-14; Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Presenter: Roger Stupp MD, Director, University Hospital Cancer Center, University of Zurich, Zurich, Switzerland
Kaur noted that CCN1 helps regulate cellular functions that include adhesion, migration, and proliferation, and that it is overexpressed in 68 percent of glioblastoma specimens.
The trial was designed as a randomized controlled phase II proof of concept study in GBM, which is an exception in phase II development, but in this way it was clearly demonstrated to our investors and potential licensing partners that APG101 is efficacious and offers a new treatment option for glioblastoma patients,' said Dr Harald Fricke, Chief Medical Officer of Apogenix GmbH.
Analyses of PRiDe, a registry of 457 recurrent glioblastoma patients, demonstrate that patients treated with the NovoTTF-100A System at their first and second recurrences had median overall survivals of 20.
Zhongming Zhao and colleagues at Vanderbilt University, in Tennessee, explain how problems that occur during the transcription of the genetic code for making proteins may play a role in the formation of a glioblastoma.
As part of the expanded collaboration, Merck has agreed to support MDxHealth's development and regulatory activities for the MGMT test and, after regulatory approval, the coordinated launch together with cilengitide in glioblastoma.