glioblastoma


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glioblastoma

 [gli″o-blas-to´mah]
any malignant astrocytoma.
glioblastoma multifor´me astrocytoma grade III or IV; a rapidly growing tumor, usually of the cerebral hemispheres, composed of spongioblasts, astroblasts, and astrocytes.

glioblastoma

/glio·blas·to·ma/ (gli″o-blas-to´mah) any malignant astrocytoma.
glioblastoma multifor´me  the most malignant type of astrocytoma, composed of spongioblasts, astroblasts, and astrocytes; it usually occurs in the brain but may occur in the brain stem or spinal cord.

glioblastoma

(glē′ō-blă-stō′mə, glī′-)
n. pl. glioblasto·mas or glioblasto·mata (-mə-tə)
A malignant tumor of the central nervous system, usually occurring in the cerebrum of adults.

glioblastoma

glioblastoma

Astrocytoma, grade III-IV, glioblastoma multiforme, malignant astrocytoma Neurosurgery A highly aggressive 1º brain tumor–BT arising in glia, comprising 30% of the 5000 new BTs/yr, US At risk occupations Anatomists, pathologists, dentists, ophthalmologists Treatment Poor response to surgery, chemotherapy, RT. See Gliadel® wafer.

glioblastoma

an undifferentiated malignant astrocytoma.

glioblastoma multiforme
a rapidly growing tumor, usually of the cerebral hemispheres, often supratentorial.
References in periodicals archive ?
CENTRIC includes patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter status.
People who undergo repeated surgeries to remove glioblastomas - the most aggressive and deadliest type of brain tumors - may survive longer than those who have a one-time operation, new Johns Hopkins research suggests.
4) Glioblastoma is the most common brain tumour, accounting for 12 - 15% of intracranial neoplasms and 50 - 60% of astrocytic tumours.
El glioblastoma multiforme primario frecuentemente muestra amplificacion, aumento de la expresion o ambos, del receptor del factor de crecimiento epidermico (Epidermal Growth Factor Receptor, EGFR), mutaciones de PTEN (delecion del cromosoma 10 para el homologo de la fosfatasa y la tensina) y perdida parcial o completa del cromosoma 10.
To study the potential of glioblastoma exosomes as markers of a tumor's genetic makeup, the research team analyzed tumor tissue and blood serum from 25 glioblastoma patients and were able both to find tumor exosomes and to identify, in some samples, a mutation in the epidermal growth factor receptor (EGFR) gene that characterizes a tumor subtype.
Patients with recurrent glioblastoma whose tumor progresses despite radiation treatment and chemotherapy do not have many options," Engelhard said.
The calcium-permeable receptors may be a therapeutic target in treating brain tumors and the introduction of a gene or chemical antagonist that blocks them is expected to become an effective glioblastoma treatment, it said.
Given the poor responsiveness of most brain tumors, and particularly of glioblastomas, to chemotherapy and radiation, and the substantial impairment of cognitive function associated with such treatments, perhaps it is time to consider whether such patients ought to be offered the possibility of trying experimental approaches before traditional ones are use," Noble wrote.
NantKwest announced that the first patient has been dosed in a first-in-human, Phase I clinical study in glioblastoma of HER2.
There is an ongoing debate regarding role of surgery for recurrent glioblastoma multiforme (GBM).
M2 EQUITYBITES-November 28, 2017-INSIGHTEC wins US FDA approval to initiate first study of Exablate Neuro to open blood-brain barrier in glioblastoma patients
M2 PHARMA-November 28, 2017-INSIGHTEC wins US FDA approval to initiate first study of Exablate Neuro to open blood-brain barrier in glioblastoma patients