2D structures of glibenclamide
(Chem Spider ID: 54809) and its coformers in.
When comparing the effect of the absence and presence of glibenclamide
, 4-AP, TEA, and apamin plus charybdotoxin on the vasorelaxation induced by clobenzorex in phenylephrine-precontracted rat aortic rings, the [E.
The outward current was completely suppressed by the antagonist glibenclamide
(1 [micro]M, Figure 1(a) bottom), which indicates that the pinacidil-elicited current is caused by the activation of sarcolemmal [K.
Aspalathus linearis produced glibenclamide
, a KATP channel blocker (Gopalakrishnan et al.
Diabetic animals were divided into three groups (n=8): Group II served as diabetic control, while group III and group IV received MFME (200 mg/kg bw) and glibenclamide
(5 mg/kg bw), respectively, for a period of 4 weeks.
The results are shown in Table 1 and suggest that HERBO-D is a potent antihyperglycemic agent and at the highest dose tested in each Group demonstrated better antihyperglycemic activity than glibenclamide
did not show any significant increase in liver glycogen level, whereas treatment with glibenclamide
and SALE 500 mg/kg; p.
, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.
Based on the extensive use,hypoglycemic action of sulfonylurea drugs and importance of metal based drugs in biomedical processes,we report the results of our studies regarding synthesis and pharmacology of complexes of Glibenclamide
with some antidiabetic potential metals.
Streptozotocin (STZ), glibenclamide
(GB), tolbutamide (TB), collagenase V and bovine serum albumin (BSA) were obtained from Sigma (St.
0 ml citrate buffer as vehicle, group 2 rats were induced with diabetes by a single intraperitoneal injection of 30 mg/kgbw of streptozotocin and kept without any treatment for 30 days, group 3 rats were induced with diabetes as mentioned in group 2 and treated with glibenclamide
Rats were treated for 20 days with daily dose of 50gg/kg [beta]-amyrin palmitate, 500[micro]g/kg glibenclamide
, a drug that is in current use for diabetes mellitus, or control.