glial fibrillary acidic protein
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Related to glial fibrillary acidic protein: Myelin basic protein
glial fibrillary acidic protein[MIM*137780]
a cytoskeletal protein of 51 kD found in fibrillary astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.
GFAPA gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish astrocytes from other glial cells, both during development and in tumour diagnostics.
Defects in GFAP are linked to Alexander disease.
gli·al fib·ril·la·ry a·cid·ic pro·tein(glī'ăl fib'ri-lar-ē ă-sid'ik prō'tēn)
A cytoskeletal protein of 51 kD found in fibrous astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.
glial fibrillary acidic proteinAbbreviation: GFAP
An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors.
See also: protein