glial fibrillary acidic protein


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Related to glial fibrillary acidic protein: Myelin basic protein

glial fibrillary acidic protein

[MIM*137780]
a cytoskeletal protein of 51 kD found in fibrillary astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

GFAP

A gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish astrocytes from other glial cells, both during development and in tumour diagnostics.

Molecular pathology
Defects in GFAP are linked to Alexander disease.

gli·al fib·ril·la·ry a·cid·ic pro·tein

(glī'ăl fib'ri-lar-ē ă-sid'ik prō'tēn)
A cytoskeletal protein of 51 kD found in fibrous astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

glial fibrillary acidic protein

Abbreviation: GFAP
An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors.
See also: protein
References in periodicals archive ?
Measurement of glial fibrillary acidic protein in human blood: analytical method and preliminary clinical results.
Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas.
The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27.
Furthermore, both HSCs and PSCs, quiescent or activated, consistently express glial fibrillary acidic protein (GFAP) (Omary et al.
Objective: This study aims to determine expression of Glial Fibrillary Acidic Protein and of Alpha Smooth Muscle Actin (a-SMA) in hepatic stellate cells of CHC cases and their association with stage of fibrosis.
2) Positivity for keratins, smooth muscle actin, collagen II, desmin, leu-7, and glial fibrillary acidic protein have also been described.
On immunohistochemical staining, the tumor was strongly positive for SI00, neuron-specific enolase, and vimentin and was weakly positive for glial fibrillary acidic protein stain (Table 1).
In normal liver, HSCs contain lipid droplets of retinoid and express glial fibrillary acidic protein (GFAP) (Buniatian et al.
Immunohistochemical marker [IHC] Glial Fibrillary Acidic Protein [GFAP] confirmed the diagnosis[Figure 3].
Glucocorticoids regulate the synthesis of glial fibrillary acidic protein in intact and adrenalectomized rats but do not affect its expression following brain injury.
In the January issue of Clinical Chemistry, Foerch and colleagues (1) report on the diagnostic accuracy of plasma glial fibrillary acidic protein (GFAP) [2] for differentiating intracerebral hemorrhage (ICH) and cerebral ischemia in patients with symptoms of acute stroke.
Methods: Different neuroanatomical areas including frontal cortex (FC), cerebellum (CB), caudate nucleus (CD) and substantia nigra (SN) from autopsy human brains (n=9) with varying PMI (4-18 h) were analyzed for pH, protein insolubility, protein oxidation/nitration and protein expression of glial fibrillary acidic protein (GFAP), synatophysin and neurofilament (NF).