glial fibrillary acidic protein


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Related to glial fibrillary acidic protein: Myelin basic protein

glial fibrillary acidic protein

[MIM*137780]
a cytoskeletal protein of 51 kD found in fibrillary astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

GFAP

A gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish astrocytes from other glial cells, both during development and in tumour diagnostics.

Molecular pathology
Defects in GFAP are linked to Alexander disease.

gli·al fib·ril·la·ry a·cid·ic pro·tein

(glī'ăl fib'ri-lar-ē ă-sid'ik prō'tēn)
A cytoskeletal protein of 51 kD found in fibrous astrocytes; stains for this protein are frequently used to assist in the differential diagnosis of neurologic lesions.

glial fibrillary acidic protein

Abbreviation: GFAP
An intermediate filament found only in astrocytes and astroglial cells. It forms part of the skeletal structure of neurons. Abnormalities in GFAP are found in a variety of neurological diseases, including Alzheimer's disease, Creutzfeldt-Jakob disease, and some brain tumors.
See also: protein
References in periodicals archive ?
Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder.
Immunostains with glial fibrillary acidic protein ([GFAP] clone GAS; DBS), melanoma marker (clone HMB-45; DBS), epithelial membrane antigen ([EMA] clone GP1.
Protein S-10013, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients.
10) PLGAmay stain with glial fibrillary acidic protein (GFAP), but this is usually less consistent than is GFAP staining of pleomorphic adenomas.
A recent study found that expression of glial fibrillary acidic protein and CD57 could be reliably used in cell block preparations to differentiate pleomorphic adenoma from ACC.
Immunostaining was performed with glial fibrillary acidic protein, neurofilament protein, S-100, and the proliferation index MIB-1 (Ki-67).
Glial fibrillary acidic protein (GFAP), found only in glial cells of the central nervous system (CNS) (1, 2), was first isolated by Eng et al.
The pituicytoma, or infundibuloma, is a rare tumor of the sellar region that displays a spindle cell morphology, fascicular arrangement of tumor cells, and variable glial fibrillary acidic protein (GFAP) immunoreactivity.
Masson's strichrome staining or an S-100 protein and glial fibrillary acidic protein (GFAP) are most helpful in accentuating the neural tissue in the background fibrosis (figure 2).
Glial fibrillary acidic protein immunostains highlight the often evenly spaced reactive astrocytes and their processes.