GDNF

(redirected from glial cell-derived neurotrophic factor)

GDNF

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
The data demonstrate that unlike Glial cell-Derived Neurotrophic Factor (GDNF), MANF significantly reduces behavioral deficits, increases dopaminergic (DA) nerve terminal reinnervation of the striatum, and increases dopamine concentrations in the striatum when MANF is administered directly to the substantia nigra (SNc).
The stress-vulnerable mice had a lower level of gene expression for glial cell-derived neurotrophic factor (Gdnf).
Earlier studies had suggested that a protein called glial cell-derived neurotrophic factor (GDNF) protects dopamine-producing neurons in patients with Parkinson's disease and that neurons produce GDNF, just as they do BDNF, in response to exercise.