GDNF

(redirected from glial cell-derived neurotrophic factor)

GDNF

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
In a previously published report of this neuropathological cohort, the team examined a number of markers of neurodegeneration including S100B, the soluble form of the receptor for advanced glycation end-products (sRAGE); glial cell-derived neurotrophic factor (GDNF); and amyloid beta (AB) 40 and AB42 (J Alzheimers Dis.
The neurotrophic factors secreted by the company's patented cells include Glial Cell-Derived Neurotrophic Factor (GDNF), Brain-Derived Neurotrophic Factor (BDNF), and Vascular Endothelial Growth Factor (VEGF), known to support the neural cell network by protection of existing motor neurons, promotion of motor neuron growth, and re-establishment of nerve-muscle interaction.
According to the company, the neurotrophic factors secreted by its patented cells include Glial Cell-Derived Neurotrophic Factor (GDNF), Brain-Derived Neurotrophic Factor (BDNF) and Vascular Endothelial Growth Factor (VEGF).
The stress-vulnerable mice had a lower level of gene expression for glial cell-derived neurotrophic factor (Gdnf).
Earlier studies had suggested that a protein called glial cell-derived neurotrophic factor (GDNF) protects dopamine-producing neurons in patients with Parkinson's disease and that neurons produce GDNF, just as they do BDNF, in response to exercise.
The glial cell-derived neurotrophic factor (GDNF), which was first characterized by its action in the central nervous system, has been shown to play a role in the development of other organs.