glial cell line-derived neurotrophic factor


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glial cell line-derived neurotrophic factor (GDNF)

[glī′əl]
a nerve growth drug that has been used in laboratory animals to reverse the progression of symptoms of Parkinson's disease and other brain diseases. GDNF is believed to act as a biological shield, protecting nerve cells from damage that normally would destroy them.

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
A research team from Anhui University of Chinese Medicine in China conducted their study on rats to verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes and found that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor also increased in the ventral tegmental area following acupuncture.
Neurturin is a member of the same protein family as glial cell line-derived neurotrophic factor (GDNF).
These molecules include neurotrophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor [20,67-69].
Patients taking part in the latest study had the experimental drug glial cell line-derived neurotrophic factor (GDNF) pumped through a tiny catheter into the part of the brain damaged by the disease.
Amgen halted tests of GDNF, shorthand for glial cell line-derived neurotrophic factor drug, on 48 patients last year after more than a year of tests.
By adding a special protein substance that protects nerves called glial cell line-derived neurotrophic factor, the team discovered the stem cells can continuously proliferate in vitro.
Upregulation of glial cell line-derived neurotrophic factor (GDNF) in the rat cochlea following noise.
Amgen (Nasdaq:AMGN), the world's largest biotechnology company, today announced that the Phase 2 study of its novel glial cell line-derived neurotrophic factor, or GDNF, for the treatment of advanced Parkinson's disease did not meet the primary study endpoint upon completion of six months of the double-blind treatment phase of the study.
Called Glial Cell Line-Derived Neurotrophic Factor, or GDNF, the drug has been shown to reverse Parkinson's disease symptoms in preclinical trials.
12, 1996--Amgen (NASDAQ:AMGN) Monday announced that it has begun the first human clinical trial of its novel neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor (GDNF) in people with Parkinson's disease.
The protein, known as glial cell line-derived neurotrophic factor (GDNF), is injected once a month through a port just behind the ear and pushed through the tubes and catheters by an external pump.
Mandel's research group has concentrated on using an adeno-associated virus to engineer brain cells in animal models with genes that can protect dopamine-producing cells, which then do the vital work of producing glial cell line-derived neurotrophic factor (GDNF).