FGF9(redirected from glia-activating factor GAF)
FGF9A gene on chromosome 13q11-q12 that encodes fibroblast growth factor 9 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF9 is produced mainly by neurons and may be important for glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumours. FGF9 interacts with FGF receptors FGFR1, -2, -3 and -4.
Defects in FGF9 cause multiple synostoses syndrome type 3.