CHST4

(redirected from glcNAc6ST-2)

CHST4

A gene on chromosome 16q22.2 that encodes a sulfotransferase which catalyses the transfer of sulfate to residues within mucin-associated glycans. These glycans serve as L-selectin ligands, which are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing to sites of inflammation.

Molecular pathology
CHST4 is expressed in colonic mucinous adenocarcinoma.
References in periodicals archive ?
x] structures, HEV ECs express a set of glycosyltransferases, including [alpha]1,3-fucosyltransferases IV and VII, Core1-[beta]3GlcNAcT (also known as [beta]3GlcNAcT-3 or Core1-GlcNAcT), Core2-[beta]1,6GlcNAcT (Core2-GlcNAcT), GlcNAc6ST-1, and GlcNAc6ST-2.