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glandular differentiation

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glandular differentiation
The appearance in a carcinoma of glands and gland-like elements which, in an adenoCA, indicates some maturation, which generally is associated with a better prognosis


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I found and read an original article, titled "Histologic Variants of Infiltrating Urothelial Carcinoma" by Zhai et al,1 which had the sentence "Although urothelial carcinoma with glandular differentiation will show positive staining for CK7 and negative staining for villin, CDX2, and CK20, metastatic adenocarcinoma of the colon is CK7 negative and shows positive staining for villin, CDX2, and CK20,10" on page 1245.
Much like the more common MMMTs of ovarian and endometrial origin, MMMTs of the fallopian tube show carcinomatous elements with predominantly glandular differentiation which may assume endometrioid, clear cell, and papillary serous patterns; less commonly, squamous differentiation or undifferentiated carcinomas may be seen.
Rare periodic acid-Schiff, postdiastase digestion periodic acid-Schiff, and mucicarmine-positive intracytoplasmic material (Figure 3, b) was demonstrated in some tumor cells, which suggested glandular differentiation.
 
 
 
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