glandular differentiation

glandular differentiation

The appearance in a carcinoma of glands and gland-like elements which, in an adenoCA, indicates some maturation, which generally is associated with a better prognosis
References in periodicals archive ?
21 Moreover, we found a significant association between glandular differentiation and patient's age.
48,70,76,78-84) A recent study showed that both entities demonstrate similar CK staining profiles, with evidence of both squamous and glandular differentiation.
Additionally, the tumor showed no glandular differentiation, making metastatic pancreatic adenocarcinoma unlikely.
Nottinghams score was assessed in which the score for glandular differentiation was 2(10-75% of tumor areas forming glandular /tubular structures), score for nuclear pleomorphism was 3(vesicular nuclei with prominent nucleoli exhibiting marked variation in size and shape), score for mitotic rate was 3(>8mitosis/10mm.
Immunohistochemistry was also performed, highlighting Carcinoembryonic Antigen (CEA) with elongated cells that line the cavities that support glandular differentiation.
There was no evidence of squamous or glandular differentiation.
1 As the nomenclature implies, these tumors possess morphological features suggestive of both carcinoid and glandular differentiation.
In a study of 165 transurethral resections, Billis and colleagues noted that 7% of patients showed squamous or glandular differentiation.
Histology revealed a 7 cm small cell carcinoma of the bladder with areas of glandular differentiation invading through the muscularis propria.
Histopathologically, many features of ASC overlap those of desmoplastic SCC, but ASC differs in having glandular differentiation.
1 Another study reported 3 cases of SCC out of 7 cases in series of MBC; 01 pure SCC, 01 mixed SCC with glandular differentiation, and 01 mixed SCC with spindle cell sarcoma component.