ginkgolides

ginkgolides

Alternative pharmacology
A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions.
References in periodicals archive ?
Sites of synthesis, translocation and accumulation of ginkgolides and bilobalide.
With regard to composition, flavonoids--such as lipoxygenase and phospholipase A2--comprise 22-27% of GBE, whereas terpene lactones-including ginkgolides A, B, C, J, and bilobalide--comprise 5-7% of GBE (Kwak et al.
A new geranylgeranyl diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides.
Amyloid-[beta]-induced pathological behaviors are suppressed by Ginkgo biloba extract EGB 761 and ginkgolides in transgenic Caenorhabditis elegans," Journal of Neuroscience, vol.
However, ginkgolides has a cage skeleton consisting of six five-membered rings, therefore, are very tough to be synthesized and they have their specific mode of action against selected pathophysiological condition cause by PAF.
The main active ingredients of ginkgo biloba extract (GbE) are flavonoids (including meletin, kaempferol and isorhamnetin) and laetones (including ginkgolides and bilobalide).
Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury.
Terpenoids consist of ginkgolides and bilobalide that inhibit platelet activating factor (PAF) which in consequence reduce the blood viscosity.
Ginkgo terpenoids consisting of two classes of compounds, ginkgolides and bilobalides (terpenic lactone and terpenic trilactone respectively), have been shown in several studies to minimise ischemia induced neurotoxicity and inhibit glutamate induced excitotoxicity (Chandrasekran 2002, Klein 1997, Prehen 1993).
Ginkgo leaf extract contains antioxidant compounds called ginkgolides and bilobalides which help scavenge free radicals that attack nearly all components of the cell, including DNA.
1) Standardized extracts, such as EGb761 or LI1370, contain 22-27% flavone glycosides and 5-7% terpene lactones (~3% ginkgolides and ~3% bilobalide).
The terpenoids are sesquiterpene bilobalide, trilactones ginkgolides A, B, and C (15, 27).